node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAN | ADAMTS1 | ENSBTAP00000021512 | ENSBTAP00000000944 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | ADAM metallopeptidase with thrombospondin type 1 motif 1. | 0.676 |
ACAN | FBLN1 | ENSBTAP00000021512 | ENSBTAP00000071425 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. | 0.893 |
ACAN | FBLN2 | ENSBTAP00000021512 | ENSBTAP00000074067 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Fibulin 2. | 0.784 |
ACAN | MMP13 | ENSBTAP00000021512 | ENSBTAP00000020045 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...] | 0.939 |
ACAN | MMP9 | ENSBTAP00000021512 | ENSBTAP00000027556 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). Belongs to the peptidase M10A family. | 0.723 |
ACAN | TIMP2 | ENSBTAP00000021512 | ENSBTAP00000014476 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family. | 0.592 |
ACAN | TIMP3 | ENSBTAP00000021512 | ENSBTAP00000027504 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. | 0.699 |
ACAN | VCAN | ENSBTAP00000021512 | ENSBTAP00000067301 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Versican core protein; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. | 0.526 |
ADAMTS1 | ACAN | ENSBTAP00000000944 | ENSBTAP00000021512 | ADAM metallopeptidase with thrombospondin type 1 motif 1. | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | 0.676 |
ADAMTS1 | AREG | ENSBTAP00000000944 | ENSBTAP00000024140 | ADAM metallopeptidase with thrombospondin type 1 motif 1. | Amphiregulin. | 0.641 |
ADAMTS1 | FBLN1 | ENSBTAP00000000944 | ENSBTAP00000071425 | ADAM metallopeptidase with thrombospondin type 1 motif 1. | Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. | 0.560 |
ADAMTS1 | FBLN2 | ENSBTAP00000000944 | ENSBTAP00000074067 | ADAM metallopeptidase with thrombospondin type 1 motif 1. | Fibulin 2. | 0.564 |
ADAMTS1 | HBEGF | ENSBTAP00000000944 | ENSBTAP00000029015 | ADAM metallopeptidase with thrombospondin type 1 motif 1. | Heparin binding EGF like growth factor. | 0.580 |
ADAMTS1 | MMP13 | ENSBTAP00000000944 | ENSBTAP00000020045 | ADAM metallopeptidase with thrombospondin type 1 motif 1. | Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...] | 0.526 |
ADAMTS1 | MMP9 | ENSBTAP00000000944 | ENSBTAP00000027556 | ADAM metallopeptidase with thrombospondin type 1 motif 1. | Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). Belongs to the peptidase M10A family. | 0.561 |
ADAMTS1 | TIMP2 | ENSBTAP00000000944 | ENSBTAP00000014476 | ADAM metallopeptidase with thrombospondin type 1 motif 1. | Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family. | 0.553 |
ADAMTS1 | TIMP3 | ENSBTAP00000000944 | ENSBTAP00000027504 | ADAM metallopeptidase with thrombospondin type 1 motif 1. | Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. | 0.660 |
ADAMTS1 | VCAN | ENSBTAP00000000944 | ENSBTAP00000067301 | ADAM metallopeptidase with thrombospondin type 1 motif 1. | Versican core protein; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. | 0.575 |
AREG | ADAMTS1 | ENSBTAP00000024140 | ENSBTAP00000000944 | Amphiregulin. | ADAM metallopeptidase with thrombospondin type 1 motif 1. | 0.641 |
AREG | HBEGF | ENSBTAP00000024140 | ENSBTAP00000029015 | Amphiregulin. | Heparin binding EGF like growth factor. | 0.761 |