node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHTF18 | CHTF8 | ENSBTAP00000026311 | ENSBTAP00000057448 | Chromosome transmission fidelity factor 18. | Decreased expression in renal and prostate cancer protein; Potential tumor suppressor; Belongs to the DERPC family. | 0.950 |
CHTF18 | DSCC1 | ENSBTAP00000026311 | ENSBTAP00000020389 | Chromosome transmission fidelity factor 18. | DNA replication and sister chromatid cohesion 1. | 0.999 |
CHTF18 | RFC1 | ENSBTAP00000026311 | ENSBTAP00000065608 | Chromosome transmission fidelity factor 18. | Replication factor C subunit 1. | 0.874 |
CHTF18 | RFC2 | ENSBTAP00000026311 | ENSBTAP00000024740 | Chromosome transmission fidelity factor 18. | Replication factor C subunit 2; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity). | 0.966 |
CHTF18 | RFC3 | ENSBTAP00000026311 | ENSBTAP00000014278 | Chromosome transmission fidelity factor 18. | Replication factor C subunit 3; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. | 0.962 |
CHTF18 | RFC4 | ENSBTAP00000026311 | ENSBTAP00000067213 | Chromosome transmission fidelity factor 18. | Replication factor C subunit 4. | 0.971 |
CHTF18 | RNF113A | ENSBTAP00000026311 | ENSBTAP00000007927 | Chromosome transmission fidelity factor 18. | E3 ubiquitin-protein ligase RNF113A; Required for pre-mRNA splicing as component of the spliceosome. E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins. Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains. Plays a role in DNA repair via its role in the synthesis of 'Lys-63'- linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents. Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling. | 0.516 |
CHTF18 | UHRF2 | ENSBTAP00000026311 | ENSBTAP00000027737 | Chromosome transmission fidelity factor 18. | Ubiquitin like with PHD and ring finger domains 2. | 0.406 |
CHTF8 | CHTF18 | ENSBTAP00000057448 | ENSBTAP00000026311 | Decreased expression in renal and prostate cancer protein; Potential tumor suppressor; Belongs to the DERPC family. | Chromosome transmission fidelity factor 18. | 0.950 |
CHTF8 | DSCC1 | ENSBTAP00000057448 | ENSBTAP00000020389 | Decreased expression in renal and prostate cancer protein; Potential tumor suppressor; Belongs to the DERPC family. | DNA replication and sister chromatid cohesion 1. | 0.800 |
CHTF8 | RFC1 | ENSBTAP00000057448 | ENSBTAP00000065608 | Decreased expression in renal and prostate cancer protein; Potential tumor suppressor; Belongs to the DERPC family. | Replication factor C subunit 1. | 0.885 |
CHTF8 | RFC2 | ENSBTAP00000057448 | ENSBTAP00000024740 | Decreased expression in renal and prostate cancer protein; Potential tumor suppressor; Belongs to the DERPC family. | Replication factor C subunit 2; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity). | 0.767 |
CHTF8 | RFC3 | ENSBTAP00000057448 | ENSBTAP00000014278 | Decreased expression in renal and prostate cancer protein; Potential tumor suppressor; Belongs to the DERPC family. | Replication factor C subunit 3; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. | 0.851 |
CHTF8 | RFC4 | ENSBTAP00000057448 | ENSBTAP00000067213 | Decreased expression in renal and prostate cancer protein; Potential tumor suppressor; Belongs to the DERPC family. | Replication factor C subunit 4. | 0.714 |
CHTF8 | RNF113A | ENSBTAP00000057448 | ENSBTAP00000007927 | Decreased expression in renal and prostate cancer protein; Potential tumor suppressor; Belongs to the DERPC family. | E3 ubiquitin-protein ligase RNF113A; Required for pre-mRNA splicing as component of the spliceosome. E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins. Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains. Plays a role in DNA repair via its role in the synthesis of 'Lys-63'- linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents. Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling. | 0.664 |
CHTF8 | RNF138 | ENSBTAP00000057448 | ENSBTAP00000026851 | Decreased expression in renal and prostate cancer protein; Potential tumor suppressor; Belongs to the DERPC family. | E3 ubiquitin-protein ligase RNF138; E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination. Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination. Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex [...] | 0.598 |
CHTF8 | TCEA1 | ENSBTAP00000057448 | ENSBTAP00000004499 | Decreased expression in renal and prostate cancer protein; Potential tumor suppressor; Belongs to the DERPC family. | Transcription elongation factor A protein 1; Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus (By similarity). Belongs to the TFS-II family. | 0.589 |
CHTF8 | UHRF2 | ENSBTAP00000057448 | ENSBTAP00000027737 | Decreased expression in renal and prostate cancer protein; Potential tumor suppressor; Belongs to the DERPC family. | Ubiquitin like with PHD and ring finger domains 2. | 0.597 |
DSCC1 | CHTF18 | ENSBTAP00000020389 | ENSBTAP00000026311 | DNA replication and sister chromatid cohesion 1. | Chromosome transmission fidelity factor 18. | 0.999 |
DSCC1 | CHTF8 | ENSBTAP00000020389 | ENSBTAP00000057448 | DNA replication and sister chromatid cohesion 1. | Decreased expression in renal and prostate cancer protein; Potential tumor suppressor; Belongs to the DERPC family. | 0.800 |