node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD63 | RAB27A | ENSBTAP00000072764 | ENSBTAP00000016464 | CD63 antigen; Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal tr [...] | RAB27A protein. | 0.875 |
CD63 | RAB27B | ENSBTAP00000072764 | ENSBTAP00000070586 | CD63 antigen; Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal tr [...] | Ras-related protein Rab-27B; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (By similarity). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (By similarity). May be involved in targeting uroplakins to urothelial apical membranes. | 0.884 |
CD63 | TSG101 | ENSBTAP00000072764 | ENSBTAP00000018032 | CD63 antigen; Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal tr [...] | Tumor susceptibility 101. | 0.989 |
G5E5G7_BOVIN | RAB27A | ENSBTAP00000018111 | ENSBTAP00000016464 | Tetraspanin. | RAB27A protein. | 0.731 |
G5E5G7_BOVIN | RAB27B | ENSBTAP00000018111 | ENSBTAP00000070586 | Tetraspanin. | Ras-related protein Rab-27B; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (By similarity). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (By similarity). May be involved in targeting uroplakins to urothelial apical membranes. | 0.693 |
G5E5G7_BOVIN | TSG101 | ENSBTAP00000018111 | ENSBTAP00000018032 | Tetraspanin. | Tumor susceptibility 101. | 0.880 |
MYRIP | RAB27A | ENSBTAP00000059992 | ENSBTAP00000016464 | Myosin VIIA and Rab interacting protein. | RAB27A protein. | 0.972 |
MYRIP | RAB27B | ENSBTAP00000059992 | ENSBTAP00000070586 | Myosin VIIA and Rab interacting protein. | Ras-related protein Rab-27B; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (By similarity). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (By similarity). May be involved in targeting uroplakins to urothelial apical membranes. | 0.765 |
MYRIP | STX4 | ENSBTAP00000059992 | ENSBTAP00000009899 | Myosin VIIA and Rab interacting protein. | Syntaxin-4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. May also play a role in docking of synaptic vesicles at presynaptic active zones (By similarity). | 0.681 |
MYRIP | SYTL2 | ENSBTAP00000059992 | ENSBTAP00000062129 | Myosin VIIA and Rab interacting protein. | Synaptotagmin-like protein 2; May act as a RAB27A effector protein and play a role in cytotoxic granule exocytosis in lymphocytes. | 0.654 |
RAB27A | CD63 | ENSBTAP00000016464 | ENSBTAP00000072764 | RAB27A protein. | CD63 antigen; Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal tr [...] | 0.875 |
RAB27A | G5E5G7_BOVIN | ENSBTAP00000016464 | ENSBTAP00000018111 | RAB27A protein. | Tetraspanin. | 0.731 |
RAB27A | MYRIP | ENSBTAP00000016464 | ENSBTAP00000059992 | RAB27A protein. | Myosin VIIA and Rab interacting protein. | 0.972 |
RAB27A | RAB27B | ENSBTAP00000016464 | ENSBTAP00000070586 | RAB27A protein. | Ras-related protein Rab-27B; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (By similarity). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (By similarity). May be involved in targeting uroplakins to urothelial apical membranes. | 0.711 |
RAB27A | RPH3A | ENSBTAP00000016464 | ENSBTAP00000005564 | RAB27A protein. | Rabphilin-3A; Plays an essential role in docking and fusion steps of regulated exocytosis (By similarity). At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP- dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release. In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Plays also a role in the exocytosis of arginine vasopressin hormone (By similarity). | 0.774 |
RAB27A | STX4 | ENSBTAP00000016464 | ENSBTAP00000009899 | RAB27A protein. | Syntaxin-4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. May also play a role in docking of synaptic vesicles at presynaptic active zones (By similarity). | 0.596 |
RAB27A | SYTL2 | ENSBTAP00000016464 | ENSBTAP00000062129 | RAB27A protein. | Synaptotagmin-like protein 2; May act as a RAB27A effector protein and play a role in cytotoxic granule exocytosis in lymphocytes. | 0.900 |
RAB27A | SYTL4 | ENSBTAP00000016464 | ENSBTAP00000058233 | RAB27A protein. | Synaptotagmin like 4. | 0.728 |
RAB27A | SYTL5 | ENSBTAP00000016464 | ENSBTAP00000006517 | RAB27A protein. | Synaptotagmin like 5. | 0.827 |
RAB27A | TSG101 | ENSBTAP00000016464 | ENSBTAP00000018032 | RAB27A protein. | Tumor susceptibility 101. | 0.726 |