STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (667 aa)    
Predicted Functional Partners:
FAM117A
Family with sequence similarity 117 member A.
   
  
 0.768
SIPA1L1
Signal induced proliferation associated 1 like 1.
    
 
 0.750
TMEM86A
Lysoplasmalogenase-like protein TMEM86A.
      
 0.699
DLG5
Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family.
    
 
 0.693
LHFPL2
LHFPL tetraspan subfamily member 2.
      
 0.675
TMEM51
Transmembrane protein 51.
   
  
 0.658
FBLIM1
Filamin-binding LIM protein 1; Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion (By similarity).
   
  
 0.620
INKA1
Inka box actin regulator 1.
   
  
 0.611
SHANK3
SH3 and multiple ankyrin repeat domains 3.
   
 
 0.609
MBIP
MAP3K12 binding inhibitory protein 1.
    
 
 0.596
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.