STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KCNN4Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4. (257 aa)    
Predicted Functional Partners:
KCNMA1
Calcium-activated potassium channel subunit alpha-1; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the c [...]
     
 0.965
KCNQ1
Uncharacterized protein; Belongs to the potassium channel family.
   
 
 0.961
KCNE3
Potassium voltage-gated channel subfamily E regulatory subunit 3.
     
 0.956
KCNMB4
Potassium calcium-activated channel subfamily M regulatory beta subunit 4.
     
 0.948
KCNJ13
Potassium voltage-gated channel subfamily J member 13.
   
 
 0.934
KCNK5
Potassium two pore domain channel subfamily K member 5; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
     
 0.929
KCNN1
Potassium calcium-activated channel subfamily N member 1.
  
  
0.928
KCNN2
Potassium calcium-activated channel subfamily N member 2.
  
  
0.926
KCNN3
Potassium calcium-activated channel subfamily N member 3.
  
  
0.925
KCNU1
Potassium calcium-activated channel subfamily U member 1.
     
 0.924
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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