node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CYP51A1 | DHCR24 | ENSBTAP00000002582 | ENSBTAP00000069716 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | 24-dehydrocholesterol reductase. | 0.994 |
CYP51A1 | DHCR7 | ENSBTAP00000002582 | ENSBTAP00000021892 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | 7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC); Belongs to the ERG4/ERG24 family. | 0.975 |
CYP51A1 | EBP | ENSBTAP00000002582 | ENSBTAP00000012234 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | Emopamil binding protein (Sterol isomerase). | 0.655 |
CYP51A1 | HSD17B7 | ENSBTAP00000002582 | ENSBTAP00000007841 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | Hydroxysteroid 17-beta dehydrogenase 7. | 0.994 |
CYP51A1 | LBR | ENSBTAP00000002582 | ENSBTAP00000011125 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | Lamin B receptor. | 0.991 |
CYP51A1 | LSS | ENSBTAP00000002582 | ENSBTAP00000025201 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | Lanosterol synthase; Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency. | 0.999 |
CYP51A1 | MSMO1 | ENSBTAP00000002582 | ENSBTAP00000003991 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | Methylsterol monooxygenase 1; Belongs to the sterol desaturase family. | 0.999 |
CYP51A1 | SC5D | ENSBTAP00000002582 | ENSBTAP00000072762 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | Sterol-C5-desaturase; Belongs to the sterol desaturase family. | 0.976 |
CYP51A1 | SOAT1 | ENSBTAP00000002582 | ENSBTAP00000033865 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | O-acyltransferase. | 0.457 |
DHCR24 | CYP51A1 | ENSBTAP00000069716 | ENSBTAP00000002582 | 24-dehydrocholesterol reductase. | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | 0.994 |
DHCR24 | DHCR7 | ENSBTAP00000069716 | ENSBTAP00000021892 | 24-dehydrocholesterol reductase. | 7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC); Belongs to the ERG4/ERG24 family. | 0.994 |
DHCR24 | EBP | ENSBTAP00000069716 | ENSBTAP00000012234 | 24-dehydrocholesterol reductase. | Emopamil binding protein (Sterol isomerase). | 0.949 |
DHCR24 | HSD17B7 | ENSBTAP00000069716 | ENSBTAP00000007841 | 24-dehydrocholesterol reductase. | Hydroxysteroid 17-beta dehydrogenase 7. | 0.981 |
DHCR24 | LBR | ENSBTAP00000069716 | ENSBTAP00000011125 | 24-dehydrocholesterol reductase. | Lamin B receptor. | 0.957 |
DHCR24 | LSS | ENSBTAP00000069716 | ENSBTAP00000025201 | 24-dehydrocholesterol reductase. | Lanosterol synthase; Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency. | 0.986 |
DHCR24 | MSMO1 | ENSBTAP00000069716 | ENSBTAP00000003991 | 24-dehydrocholesterol reductase. | Methylsterol monooxygenase 1; Belongs to the sterol desaturase family. | 0.988 |
DHCR24 | SC5D | ENSBTAP00000069716 | ENSBTAP00000072762 | 24-dehydrocholesterol reductase. | Sterol-C5-desaturase; Belongs to the sterol desaturase family. | 0.985 |
DHCR24 | SOAT1 | ENSBTAP00000069716 | ENSBTAP00000033865 | 24-dehydrocholesterol reductase. | O-acyltransferase. | 0.930 |
DHCR24 | SOAT2 | ENSBTAP00000069716 | ENSBTAP00000007392 | 24-dehydrocholesterol reductase. | O-acyltransferase. | 0.926 |
DHCR7 | CYP51A1 | ENSBTAP00000021892 | ENSBTAP00000002582 | 7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC); Belongs to the ERG4/ERG24 family. | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | 0.975 |