node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGEF10 | ERICH1 | ENSBTAP00000011327 | ENSBTAP00000022730 | Rho guanine nucleotide exchange factor 10. | Glutamate rich 1. | 0.577 |
ARHGEF10 | FBXO25 | ENSBTAP00000011327 | ENSBTAP00000068225 | Rho guanine nucleotide exchange factor 10. | F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity). | 0.632 |
ARHGEF10 | TDRP | ENSBTAP00000011327 | ENSBTAP00000053800 | Rho guanine nucleotide exchange factor 10. | Testis development related protein. | 0.569 |
CUL1 | FBXL14 | ENSBTAP00000063991 | ENSBTAP00000058517 | Cullin 1; Belongs to the cullin family. | F-box/LRR-repeat protein 14; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1 (By similarity). | 0.848 |
CUL1 | FBXL15 | ENSBTAP00000063991 | ENSBTAP00000003249 | Cullin 1; Belongs to the cullin family. | F-box/LRR-repeat protein 15; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity); Belongs to the FBXL15 family. | 0.795 |
CUL1 | FBXO25 | ENSBTAP00000063991 | ENSBTAP00000068225 | Cullin 1; Belongs to the cullin family. | F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity). | 0.728 |
CUL1 | FBXO33 | ENSBTAP00000063991 | ENSBTAP00000008982 | Cullin 1; Belongs to the cullin family. | F-box protein 33. | 0.718 |
CUL1 | FBXW5 | ENSBTAP00000063991 | ENSBTAP00000072648 | Cullin 1; Belongs to the cullin family. | F-box and WD repeat domain containing 5. | 0.864 |
CUL1 | SKP1 | ENSBTAP00000063991 | ENSBTAP00000035184 | Cullin 1; Belongs to the cullin family. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.999 |
ERICH1 | ARHGEF10 | ENSBTAP00000022730 | ENSBTAP00000011327 | Glutamate rich 1. | Rho guanine nucleotide exchange factor 10. | 0.577 |
ERICH1 | FBXO25 | ENSBTAP00000022730 | ENSBTAP00000068225 | Glutamate rich 1. | F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity). | 0.593 |
ERICH1 | TDRP | ENSBTAP00000022730 | ENSBTAP00000053800 | Glutamate rich 1. | Testis development related protein. | 0.688 |
FBXL14 | CUL1 | ENSBTAP00000058517 | ENSBTAP00000063991 | F-box/LRR-repeat protein 14; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1 (By similarity). | Cullin 1; Belongs to the cullin family. | 0.848 |
FBXL14 | FBXO25 | ENSBTAP00000058517 | ENSBTAP00000068225 | F-box/LRR-repeat protein 14; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1 (By similarity). | F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity). | 0.630 |
FBXL14 | FBXO33 | ENSBTAP00000058517 | ENSBTAP00000008982 | F-box/LRR-repeat protein 14; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1 (By similarity). | F-box protein 33. | 0.674 |
FBXL14 | FBXW5 | ENSBTAP00000058517 | ENSBTAP00000072648 | F-box/LRR-repeat protein 14; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1 (By similarity). | F-box and WD repeat domain containing 5. | 0.439 |
FBXL14 | SKP1 | ENSBTAP00000058517 | ENSBTAP00000035184 | F-box/LRR-repeat protein 14; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1 (By similarity). | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.840 |
FBXL15 | CUL1 | ENSBTAP00000003249 | ENSBTAP00000063991 | F-box/LRR-repeat protein 15; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity); Belongs to the FBXL15 family. | Cullin 1; Belongs to the cullin family. | 0.795 |
FBXL15 | FBXO25 | ENSBTAP00000003249 | ENSBTAP00000068225 | F-box/LRR-repeat protein 15; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity); Belongs to the FBXL15 family. | F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity). | 0.598 |
FBXL15 | FBXO33 | ENSBTAP00000003249 | ENSBTAP00000008982 | F-box/LRR-repeat protein 15; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity); Belongs to the FBXL15 family. | F-box protein 33. | 0.729 |