node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTL6B | DMAP1 | ENSBTAP00000063203 | ENSBTAP00000007766 | Actin-like protein 6B; Belongs to the actin family. | DNA methyltransferase 1 associated protein 1. | 0.945 |
ACTL6B | PBRM1 | ENSBTAP00000063203 | ENSBTAP00000058127 | Actin-like protein 6B; Belongs to the actin family. | Polybromo 1. | 0.934 |
ACTL6B | RUVBL1 | ENSBTAP00000063203 | ENSBTAP00000027964 | Actin-like protein 6B; Belongs to the actin family. | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. | 0.931 |
ACTL6B | RUVBL2 | ENSBTAP00000063203 | ENSBTAP00000031853 | Actin-like protein 6B; Belongs to the actin family. | RuvB-like 2; Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring- like structure contribute to the ATPase activity (By similarity). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (By similarity). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with oth [...] | 0.937 |
ACTL6B | SMARCA2 | ENSBTAP00000063203 | ENSBTAP00000057766 | Actin-like protein 6B; Belongs to the actin family. | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. | 0.924 |
ACTL6B | SMARCA4 | ENSBTAP00000063203 | ENSBTAP00000059124 | Actin-like protein 6B; Belongs to the actin family. | Transcription activator BRG1; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium- dependent release of a repressor complex and the recruitment of an activator complex. In resting ne [...] | 0.971 |
ACTL6B | SMARCB1 | ENSBTAP00000063203 | ENSBTAP00000067786 | Actin-like protein 6B; Belongs to the actin family. | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Core component of the BAF (SWI/SNF) complex. This ATP- dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structu [...] | 0.971 |
ACTL6B | SMARCD1 | ENSBTAP00000063203 | ENSBTAP00000001284 | Actin-like protein 6B; Belongs to the actin family. | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (n [...] | 0.946 |
ACTL6B | SMARCE1 | ENSBTAP00000063203 | ENSBTAP00000020356 | Actin-like protein 6B; Belongs to the actin family. | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1. | 0.919 |
ACTL6B | TRRAP | ENSBTAP00000063203 | ENSBTAP00000009365 | Actin-like protein 6B; Belongs to the actin family. | Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. | 0.938 |
DMAP1 | ACTL6B | ENSBTAP00000007766 | ENSBTAP00000063203 | DNA methyltransferase 1 associated protein 1. | Actin-like protein 6B; Belongs to the actin family. | 0.945 |
DMAP1 | RUVBL1 | ENSBTAP00000007766 | ENSBTAP00000027964 | DNA methyltransferase 1 associated protein 1. | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. | 0.988 |
DMAP1 | RUVBL2 | ENSBTAP00000007766 | ENSBTAP00000031853 | DNA methyltransferase 1 associated protein 1. | RuvB-like 2; Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring- like structure contribute to the ATPase activity (By similarity). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (By similarity). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with oth [...] | 0.985 |
DMAP1 | SMARCD1 | ENSBTAP00000007766 | ENSBTAP00000001284 | DNA methyltransferase 1 associated protein 1. | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (n [...] | 0.502 |
DMAP1 | TRRAP | ENSBTAP00000007766 | ENSBTAP00000009365 | DNA methyltransferase 1 associated protein 1. | Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. | 0.995 |
PBRM1 | ACTL6B | ENSBTAP00000058127 | ENSBTAP00000063203 | Polybromo 1. | Actin-like protein 6B; Belongs to the actin family. | 0.934 |
PBRM1 | SMARCA2 | ENSBTAP00000058127 | ENSBTAP00000057766 | Polybromo 1. | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. | 0.996 |
PBRM1 | SMARCA4 | ENSBTAP00000058127 | ENSBTAP00000059124 | Polybromo 1. | Transcription activator BRG1; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium- dependent release of a repressor complex and the recruitment of an activator complex. In resting ne [...] | 0.997 |
PBRM1 | SMARCB1 | ENSBTAP00000058127 | ENSBTAP00000067786 | Polybromo 1. | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Core component of the BAF (SWI/SNF) complex. This ATP- dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structu [...] | 0.996 |
PBRM1 | SMARCD1 | ENSBTAP00000058127 | ENSBTAP00000001284 | Polybromo 1. | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (n [...] | 0.998 |