STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SLC39A4Zinc transporter ZIP4; Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability (By similarity). (772 aa)    
Predicted Functional Partners:
SLC39A1
Zinc transporter ZIP1; Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body (By similarity). Belongs to the ZIP transporter (TC 2.A.5) family.
   
 
 0.843
SLC39A11
Zinc transporter ZIP11; Functions as a cellular zinc transporter. Belongs to the ZIP transporter (TC 2.A.5) family.
    
 
 0.840
SLC39A2
Solute carrier family 39 member 2.
   
 
 0.832
SLC39A3
Zinc transporter ZIP3; Acts as a zinc-influx transporter; Belongs to the ZIP transporter (TC 2.A.5) family.
   
 
 0.773
SLC30A6
Zinc transporter 6; Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
  
 
 0.719
SLC30A2
Solute carrier family 30 member 2.
   
 
 0.700
SLC30A4
Zinc transporter 4; Probably involved in zinc transport out of the cytoplasm, may be by sequestration into an intracellular compartment.
   
 
 0.681
FBXL6
F-box and leucine rich repeat protein 6.
   
  
 0.665
ADCK5
AarF domain containing kinase 5.
      
 0.665
SLC30A7
Zinc transporter 7; Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity).
  
 
 0.648
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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