node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FAAP100 | RAD23A | ENSBTAP00000025435 | ENSBTAP00000020113 | FA core complex associated protein 100. | UV excision repair protein RAD23 homolog A; Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'- linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome (By similarity). | 0.487 |
FAAP100 | RAD23B | ENSBTAP00000025435 | ENSBTAP00000002506 | FA core complex associated protein 100. | UV excision repair protein RAD23 homolog B; Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome (By similarity). The XPC complex is proposed to represent the first factor bound at the sites [...] | 0.460 |
FAAP100 | UBE4B | ENSBTAP00000025435 | ENSBTAP00000062125 | FA core complex associated protein 100. | Ubiquitination factor E4B. | 0.743 |
FAAP100 | UFD1 | ENSBTAP00000025435 | ENSBTAP00000064002 | FA core complex associated protein 100. | Ubiquitin recognition factor in ER associated degradation 1. | 0.895 |
FAAP100 | VCP | ENSBTAP00000025435 | ENSBTAP00000019970 | FA core complex associated protein 100. | Transitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is neces [...] | 0.780 |
FAAP100 | YOD1 | ENSBTAP00000025435 | ENSBTAP00000027017 | FA core complex associated protein 100. | Ubiquitin thioesterase OTU1; Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. A [...] | 0.863 |
HGS | UBE4B | ENSBTAP00000000527 | ENSBTAP00000062125 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ES [...] | Ubiquitination factor E4B. | 0.800 |
LHFPL1 | UBE4B | ENSBTAP00000043399 | ENSBTAP00000062125 | LHFPL tetraspan subfamily member 1. | Ubiquitination factor E4B. | 0.762 |
NMNAT1 | UBE4B | ENSBTAP00000059876 | ENSBTAP00000062125 | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1; Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less [...] | Ubiquitination factor E4B. | 0.849 |
NPLOC4 | RAD23A | ENSBTAP00000040249 | ENSBTAP00000020113 | NPL4 homolog, ubiquitin recognition factor. | UV excision repair protein RAD23 homolog A; Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'- linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome (By similarity). | 0.460 |
NPLOC4 | RAD23B | ENSBTAP00000040249 | ENSBTAP00000002506 | NPL4 homolog, ubiquitin recognition factor. | UV excision repair protein RAD23 homolog B; Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome (By similarity). The XPC complex is proposed to represent the first factor bound at the sites [...] | 0.566 |
NPLOC4 | UBE4B | ENSBTAP00000040249 | ENSBTAP00000062125 | NPL4 homolog, ubiquitin recognition factor. | Ubiquitination factor E4B. | 0.743 |
NPLOC4 | UFD1 | ENSBTAP00000040249 | ENSBTAP00000064002 | NPL4 homolog, ubiquitin recognition factor. | Ubiquitin recognition factor in ER associated degradation 1. | 0.999 |
NPLOC4 | VCP | ENSBTAP00000040249 | ENSBTAP00000019970 | NPL4 homolog, ubiquitin recognition factor. | Transitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is neces [...] | 0.999 |
NPLOC4 | YOD1 | ENSBTAP00000040249 | ENSBTAP00000027017 | NPL4 homolog, ubiquitin recognition factor. | Ubiquitin thioesterase OTU1; Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. A [...] | 0.863 |
RAD23A | FAAP100 | ENSBTAP00000020113 | ENSBTAP00000025435 | UV excision repair protein RAD23 homolog A; Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'- linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome (By similarity). | FA core complex associated protein 100. | 0.487 |
RAD23A | NPLOC4 | ENSBTAP00000020113 | ENSBTAP00000040249 | UV excision repair protein RAD23 homolog A; Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'- linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome (By similarity). | NPL4 homolog, ubiquitin recognition factor. | 0.460 |
RAD23A | RAD23B | ENSBTAP00000020113 | ENSBTAP00000002506 | UV excision repair protein RAD23 homolog A; Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'- linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome (By similarity). | UV excision repair protein RAD23 homolog B; Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome (By similarity). The XPC complex is proposed to represent the first factor bound at the sites [...] | 0.936 |
RAD23A | UBE4B | ENSBTAP00000020113 | ENSBTAP00000062125 | UV excision repair protein RAD23 homolog A; Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'- linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome (By similarity). | Ubiquitination factor E4B. | 0.711 |
RAD23A | UFD1 | ENSBTAP00000020113 | ENSBTAP00000064002 | UV excision repair protein RAD23 homolog A; Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'- linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome (By similarity). | Ubiquitin recognition factor in ER associated degradation 1. | 0.501 |