node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASAP3 | FCHSD1 | ENSBTAP00000016266 | ENSBTAP00000021194 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 3. | Uncharacterized protein. | 0.575 |
ASAP3 | SH3GLB2 | ENSBTAP00000016266 | ENSBTAP00000059438 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 3. | Endophilin-B2; Belongs to the endophilin family. | 0.574 |
ASAP3 | SNX7 | ENSBTAP00000016266 | ENSBTAP00000063602 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 3. | Sorting nexin 7. | 0.572 |
CASP3 | SH3GLB2 | ENSBTAP00000021099 | ENSBTAP00000059438 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | Endophilin-B2; Belongs to the endophilin family. | 0.750 |
DYNC1I2 | SH3GLB2 | ENSBTAP00000073452 | ENSBTAP00000059438 | Cytoplasmic dynein 1 intermediate chain 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes (By similarity). | Endophilin-B2; Belongs to the endophilin family. | 0.565 |
ENSBTAP00000058576 | SH3GLB2 | ENSBTAP00000058576 | ENSBTAP00000059438 | Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. | Endophilin-B2; Belongs to the endophilin family. | 0.698 |
FCHSD1 | ASAP3 | ENSBTAP00000021194 | ENSBTAP00000016266 | Uncharacterized protein. | ArfGAP with SH3 domain, ankyrin repeat and PH domain 3. | 0.575 |
FCHSD1 | SH3GLB1 | ENSBTAP00000021194 | ENSBTAP00000069535 | Uncharacterized protein. | Endophilin-B1; May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation. Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2). Associated with PI3KC3-C2 d [...] | 0.400 |
FCHSD1 | SH3GLB2 | ENSBTAP00000021194 | ENSBTAP00000059438 | Uncharacterized protein. | Endophilin-B2; Belongs to the endophilin family. | 0.585 |
FCHSD1 | SNX7 | ENSBTAP00000021194 | ENSBTAP00000063602 | Uncharacterized protein. | Sorting nexin 7. | 0.618 |
SH3GLB1 | FCHSD1 | ENSBTAP00000069535 | ENSBTAP00000021194 | Endophilin-B1; May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation. Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2). Associated with PI3KC3-C2 d [...] | Uncharacterized protein. | 0.400 |
SH3GLB1 | SH3GLB2 | ENSBTAP00000069535 | ENSBTAP00000059438 | Endophilin-B1; May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation. Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2). Associated with PI3KC3-C2 d [...] | Endophilin-B2; Belongs to the endophilin family. | 0.685 |
SH3GLB1 | USP14 | ENSBTAP00000069535 | ENSBTAP00000063666 | Endophilin-B1; May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation. Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2). Associated with PI3KC3-C2 d [...] | Ubiquitin carboxyl-terminal hydrolase 14; Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibi [...] | 0.837 |
SH3GLB2 | ASAP3 | ENSBTAP00000059438 | ENSBTAP00000016266 | Endophilin-B2; Belongs to the endophilin family. | ArfGAP with SH3 domain, ankyrin repeat and PH domain 3. | 0.574 |
SH3GLB2 | CASP3 | ENSBTAP00000059438 | ENSBTAP00000021099 | Endophilin-B2; Belongs to the endophilin family. | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | 0.750 |
SH3GLB2 | DYNC1I2 | ENSBTAP00000059438 | ENSBTAP00000073452 | Endophilin-B2; Belongs to the endophilin family. | Cytoplasmic dynein 1 intermediate chain 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes (By similarity). | 0.565 |
SH3GLB2 | ENSBTAP00000058576 | ENSBTAP00000059438 | ENSBTAP00000058576 | Endophilin-B2; Belongs to the endophilin family. | Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. | 0.698 |
SH3GLB2 | FCHSD1 | ENSBTAP00000059438 | ENSBTAP00000021194 | Endophilin-B2; Belongs to the endophilin family. | Uncharacterized protein. | 0.585 |
SH3GLB2 | SH3GLB1 | ENSBTAP00000059438 | ENSBTAP00000069535 | Endophilin-B2; Belongs to the endophilin family. | Endophilin-B1; May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation. Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2). Associated with PI3KC3-C2 d [...] | 0.685 |
SH3GLB2 | SNX7 | ENSBTAP00000059438 | ENSBTAP00000063602 | Endophilin-B2; Belongs to the endophilin family. | Sorting nexin 7. | 0.567 |