STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HEPACAM2HEPACAM family member 2; Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma- tubulin ring complex and promotes centrosome maturation (By similarity). (491 aa)    
Predicted Functional Partners:
KCNQ1
Uncharacterized protein; Belongs to the potassium channel family.
   
   0.801
UBXN2B
UBX domain protein 2B.
    
 
 0.650
NAPG
Gamma-soluble NSF attachment protein; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus; Belongs to the SNAP family.
      
 0.648
FIGNL1
Fidgetin like 1; Belongs to the AAA ATPase family.
    
 
 0.644
EPS15L1
Epidermal growth factor receptor pathway substrate 15 like 1.
    
 
 0.624
SH3BGRL3
SH3 domain-binding glutamic acid-rich-like protein 3; Could act as a modulator of glutaredoxin biological activity. Belongs to the SH3BGR family.
      
 0.597
EPS15L1-2
Uncharacterized protein.
    
 
 0.591
CCDC83
Coiled-coil domain-containing protein 83.
      
 0.569
FTSJ1-2
Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.
      
 0.568
RNF146
E3 ubiquitin-protein ligase RNF146-B; E3 ubiquitin-protein ligase that specifically binds poly-ADP- ribosylated proteins and mediates their ubiquitination and subsequent degradation. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate poly-ADP-ribosylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent poly-ADP- ribosylated prot [...]
    
 
 0.547
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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