STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ELF5ETS-related transcription factor Elf-5; Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation. Binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT] (By similarity). (275 aa)    
Predicted Functional Partners:
CDX2
Homeobox domain-containing protein.
      
 0.752
EOMES
Eomesodermin.
      
 0.717
GATA3
Trans-acting T-cell-specific transcription factor GATA-3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses (By similarity).
   
  
 0.716
TEAD4
TEA domain transcription factor 4.
      
 0.689
GCM1
Glial cells missing transcription factor 1.
      
 0.687
TFAP2C
Transcription factor AP-2 gamma (Activating enhancer binding protein 2 gamma).
   
  
 0.672
ESRRB
Estrogen related receptor beta.
    
 
 0.646
CSN2
Antioxidant peptide; Important role in determination of the surface properties of the casein micelles. Casohypotensin acts as a bradykinin-potentiating peptide. Induces hypotension in rats. Acts as a strong competitive inhibitor of endo-oligopeptidase A.
      
 0.606
CSN1S1
Antioxidant peptide; Important role in the capacity of milk to transport calcium phosphate; Belongs to the alpha-casein family.
   
  
 0.594
PRL
Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation.
      
 0.581
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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