STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDK18Cyclin dependent kinase 18; Belongs to the protein kinase superfamily. (471 aa)    
Predicted Functional Partners:
CCNQ
Cyclin Q; Belongs to the cyclin family.
    
 
 0.647
RAB2A
RAB2A, member RAS oncogene family.
   
 
 0.638
CDC6
Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.
    
 
 0.626
CCNY
Cyclin Y; Belongs to the cyclin family.
    
 
 0.620
CCNK
Cyclin K; Belongs to the cyclin family.
   
 
 0.610
CDKN1A
Cyclin dependent kinase inhibitor 1A.
   
 
 0.607
CDKN2C
Cyclin dependent kinase inhibitor 2C.
   
 
 0.607
GORASP2
Golgi reassembly stacking protein 2.
    
 
 0.597
ORC2
Origin recognition complex subunit 2; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3 (By similarity).
 
 
 
 0.594
CCNYL1
Cyclin Y like 1; Belongs to the cyclin family.
    
 
 0.574
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.