node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDH15 | CDH16 | ENSBTAP00000065928 | ENSBTAP00000012610 | Cadherin 15; Cadherins are calcium-dependent cell adhesion proteins. | Cadherin 16. | 0.598 |
CDH15 | CDH2 | ENSBTAP00000065928 | ENSBTAP00000028238 | Cadherin 15; Cadherins are calcium-dependent cell adhesion proteins. | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic s [...] | 0.596 |
CDH15 | CDH20 | ENSBTAP00000065928 | ENSBTAP00000002285 | Cadherin 15; Cadherins are calcium-dependent cell adhesion proteins. | Cadherin 20; Cadherins are calcium-dependent cell adhesion proteins. | 0.633 |
CDH15 | CDH4 | ENSBTAP00000065928 | ENSBTAP00000020042 | Cadherin 15; Cadherins are calcium-dependent cell adhesion proteins. | Cadherin 4; Cadherins are calcium-dependent cell adhesion proteins. | 0.593 |
CDH15 | CDH6 | ENSBTAP00000065928 | ENSBTAP00000017274 | Cadherin 15; Cadherins are calcium-dependent cell adhesion proteins. | Cadherin-6; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). | 0.615 |
CDH15 | CDH7 | ENSBTAP00000065928 | ENSBTAP00000031052 | Cadherin 15; Cadherins are calcium-dependent cell adhesion proteins. | Cadherin 7; Cadherins are calcium-dependent cell adhesion proteins. | 0.635 |
CDH15 | CTNNA1 | ENSBTAP00000065928 | ENSBTAP00000065154 | Cadherin 15; Cadherins are calcium-dependent cell adhesion proteins. | Catenin alpha-1; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and [...] | 0.729 |
CDH15 | CTNNA2 | ENSBTAP00000065928 | ENSBTAP00000056218 | Cadherin 15; Cadherins are calcium-dependent cell adhesion proteins. | Uncharacterized protein. | 0.695 |
CDH15 | CTNNB1 | ENSBTAP00000065928 | ENSBTAP00000021838 | Cadherin 15; Cadherins are calcium-dependent cell adhesion proteins. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | 0.863 |
CDH15 | JUP | ENSBTAP00000065928 | ENSBTAP00000023522 | Cadherin 15; Cadherins are calcium-dependent cell adhesion proteins. | Junction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...] | 0.771 |
CDH16 | CDH15 | ENSBTAP00000012610 | ENSBTAP00000065928 | Cadherin 16. | Cadherin 15; Cadherins are calcium-dependent cell adhesion proteins. | 0.598 |
CDH16 | CDH2 | ENSBTAP00000012610 | ENSBTAP00000028238 | Cadherin 16. | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic s [...] | 0.592 |
CDH16 | CDH20 | ENSBTAP00000012610 | ENSBTAP00000002285 | Cadherin 16. | Cadherin 20; Cadherins are calcium-dependent cell adhesion proteins. | 0.583 |
CDH16 | CDH4 | ENSBTAP00000012610 | ENSBTAP00000020042 | Cadherin 16. | Cadherin 4; Cadherins are calcium-dependent cell adhesion proteins. | 0.583 |
CDH16 | CDH6 | ENSBTAP00000012610 | ENSBTAP00000017274 | Cadherin 16. | Cadherin-6; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). | 0.684 |
CDH16 | CDH7 | ENSBTAP00000012610 | ENSBTAP00000031052 | Cadherin 16. | Cadherin 7; Cadherins are calcium-dependent cell adhesion proteins. | 0.556 |
CDH16 | CTNNA1 | ENSBTAP00000012610 | ENSBTAP00000065154 | Cadherin 16. | Catenin alpha-1; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and [...] | 0.644 |
CDH16 | CTNNA2 | ENSBTAP00000012610 | ENSBTAP00000056218 | Cadherin 16. | Uncharacterized protein. | 0.644 |
CDH16 | CTNNB1 | ENSBTAP00000012610 | ENSBTAP00000021838 | Cadherin 16. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | 0.694 |
CDH16 | JUP | ENSBTAP00000012610 | ENSBTAP00000023522 | Cadherin 16. | Junction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...] | 0.664 |