node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CLDN5 | GAPDH | ENSBTAP00000029418 | ENSBTAP00000062798 | Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space. | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | 0.672 |
CLDN5 | MFSD2A | ENSBTAP00000029418 | ENSBTAP00000017353 | Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space. | Major facilitator superfamily domain containing 2A. | 0.682 |
CLDN5 | NDP | ENSBTAP00000029418 | ENSBTAP00000016757 | Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space. | Norrin; Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt- dependent activation of FZD4, suggesting the existence of a Wnt- independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible [...] | 0.579 |
CLDN5 | OCLN | ENSBTAP00000029418 | ENSBTAP00000000734 | Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space. | Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. | 0.991 |
CSTF3 | GAPDH | ENSBTAP00000011369 | ENSBTAP00000062798 | Cleavage stimulation factor subunit 3. | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | 0.630 |
CSTF3 | MFSD2A | ENSBTAP00000011369 | ENSBTAP00000017353 | Cleavage stimulation factor subunit 3. | Major facilitator superfamily domain containing 2A. | 0.647 |
CSTF3 | TK1 | ENSBTAP00000011369 | ENSBTAP00000070231 | Cleavage stimulation factor subunit 3. | Thymidine kinase, cytosolic. | 0.485 |
GAPDH | CLDN5 | ENSBTAP00000062798 | ENSBTAP00000029418 | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space. | 0.672 |
GAPDH | CSTF3 | ENSBTAP00000062798 | ENSBTAP00000011369 | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | Cleavage stimulation factor subunit 3. | 0.630 |
GAPDH | MFSD2A | ENSBTAP00000062798 | ENSBTAP00000017353 | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | Major facilitator superfamily domain containing 2A. | 0.564 |
GAPDH | OCLN | ENSBTAP00000062798 | ENSBTAP00000000734 | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. | 0.833 |
GAPDH | SLC1A5 | ENSBTAP00000062798 | ENSBTAP00000018050 | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | Neutral amino acid transporter B(0); Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids. | 0.454 |
GAPDH | TK1 | ENSBTAP00000062798 | ENSBTAP00000070231 | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | Thymidine kinase, cytosolic. | 0.528 |
MFSD11 | MFSD2A | ENSBTAP00000056711 | ENSBTAP00000017353 | Major facilitator superfamily domain containing 11. | Major facilitator superfamily domain containing 2A. | 0.527 |
MFSD2A | CLDN5 | ENSBTAP00000017353 | ENSBTAP00000029418 | Major facilitator superfamily domain containing 2A. | Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space. | 0.682 |
MFSD2A | CSTF3 | ENSBTAP00000017353 | ENSBTAP00000011369 | Major facilitator superfamily domain containing 2A. | Cleavage stimulation factor subunit 3. | 0.647 |
MFSD2A | GAPDH | ENSBTAP00000017353 | ENSBTAP00000062798 | Major facilitator superfamily domain containing 2A. | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | 0.564 |
MFSD2A | MFSD11 | ENSBTAP00000017353 | ENSBTAP00000056711 | Major facilitator superfamily domain containing 2A. | Major facilitator superfamily domain containing 11. | 0.527 |
MFSD2A | NDP | ENSBTAP00000017353 | ENSBTAP00000016757 | Major facilitator superfamily domain containing 2A. | Norrin; Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt- dependent activation of FZD4, suggesting the existence of a Wnt- independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible [...] | 0.550 |
MFSD2A | OCLN | ENSBTAP00000017353 | ENSBTAP00000000734 | Major facilitator superfamily domain containing 2A. | Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. | 0.520 |