node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CMPK1 | CMPK2 | ENSBTAP00000026582 | ENSBTAP00000026613 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Cytidine/uridine monophosphate kinase 2. | 0.971 |
CMPK1 | NME1 | ENSBTAP00000026582 | ENSBTAP00000006106 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Nucleoside diphosphate kinase A 2; Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine- specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination; Belongs to the NDK family. | 0.932 |
CMPK1 | NME4 | ENSBTAP00000026582 | ENSBTAP00000045110 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | NDK domain-containing protein; Belongs to the NDK family. | 0.949 |
CMPK1 | NME6 | ENSBTAP00000026582 | ENSBTAP00000003935 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Nucleoside diphosphate kinase. | 0.929 |
CMPK1 | RRM1 | ENSBTAP00000026582 | ENSBTAP00000017428 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.969 |
CMPK1 | RRM2 | ENSBTAP00000026582 | ENSBTAP00000010802 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Ribonucleotide reductase regulatory subunit M2. | 0.947 |
CMPK1 | RRM2B | ENSBTAP00000026582 | ENSBTAP00000028260 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Ribonucleotide reductase regulatory TP53 inducible subunit M2B. | 0.935 |
CMPK1 | TYMS | ENSBTAP00000026582 | ENSBTAP00000009214 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. | 0.523 |
CMPK2 | CMPK1 | ENSBTAP00000026613 | ENSBTAP00000026582 | Cytidine/uridine monophosphate kinase 2. | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | 0.971 |
CMPK2 | NME1 | ENSBTAP00000026613 | ENSBTAP00000006106 | Cytidine/uridine monophosphate kinase 2. | Nucleoside diphosphate kinase A 2; Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine- specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination; Belongs to the NDK family. | 0.940 |
CMPK2 | NME4 | ENSBTAP00000026613 | ENSBTAP00000045110 | Cytidine/uridine monophosphate kinase 2. | NDK domain-containing protein; Belongs to the NDK family. | 0.949 |
CMPK2 | NME6 | ENSBTAP00000026613 | ENSBTAP00000003935 | Cytidine/uridine monophosphate kinase 2. | Nucleoside diphosphate kinase. | 0.940 |
CMPK2 | RRM1 | ENSBTAP00000026613 | ENSBTAP00000017428 | Cytidine/uridine monophosphate kinase 2. | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.957 |
CMPK2 | RRM2 | ENSBTAP00000026613 | ENSBTAP00000010802 | Cytidine/uridine monophosphate kinase 2. | Ribonucleotide reductase regulatory subunit M2. | 0.909 |
CMPK2 | RRM2B | ENSBTAP00000026613 | ENSBTAP00000028260 | Cytidine/uridine monophosphate kinase 2. | Ribonucleotide reductase regulatory TP53 inducible subunit M2B. | 0.909 |
CMPK2 | TYMS | ENSBTAP00000026613 | ENSBTAP00000009214 | Cytidine/uridine monophosphate kinase 2. | Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. | 0.754 |
GUK1 | NME1 | ENSBTAP00000068771 | ENSBTAP00000006106 | Guanylate kinase; Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP). Involved in the cGMP metabolism in photoreceptors. Belongs to the guanylate kinase family. | Nucleoside diphosphate kinase A 2; Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine- specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination; Belongs to the NDK family. | 0.957 |
GUK1 | NME4 | ENSBTAP00000068771 | ENSBTAP00000045110 | Guanylate kinase; Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP). Involved in the cGMP metabolism in photoreceptors. Belongs to the guanylate kinase family. | NDK domain-containing protein; Belongs to the NDK family. | 0.942 |
GUK1 | NME6 | ENSBTAP00000068771 | ENSBTAP00000003935 | Guanylate kinase; Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP). Involved in the cGMP metabolism in photoreceptors. Belongs to the guanylate kinase family. | Nucleoside diphosphate kinase. | 0.926 |
GUK1 | RRM1 | ENSBTAP00000068771 | ENSBTAP00000017428 | Guanylate kinase; Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP). Involved in the cGMP metabolism in photoreceptors. Belongs to the guanylate kinase family. | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.955 |