node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CAMKMT | DOT1L | ENSBTAP00000043450 | ENSBTAP00000065258 | Calmodulin-lysine N-methyltransferase. | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | 0.746 |
CAMKMT | KMT5A | ENSBTAP00000043450 | ENSBTAP00000055591 | Calmodulin-lysine N-methyltransferase. | N-lysine methyltransferase KMT5A; Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper [...] | 0.698 |
CAMKMT | PLOD1 | ENSBTAP00000043450 | ENSBTAP00000002658 | Calmodulin-lysine N-methyltransferase. | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1; Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys- Gly- sequences in collagens (By similarity). These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (By similarity). | 0.900 |
CAMKMT | PLOD3 | ENSBTAP00000043450 | ENSBTAP00000000447 | Calmodulin-lysine N-methyltransferase. | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3. | 0.900 |
CAMKMT | SETD7 | ENSBTAP00000043450 | ENSBTAP00000004658 | Calmodulin-lysine N-methyltransferase. | Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. | 0.700 |
CAMKMT | SMYD2 | ENSBTAP00000043450 | ENSBTAP00000017516 | Calmodulin-lysine N-methyltransferase. | N-lysine methyltransferase SMYD2; Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'. | 0.708 |
CAMKMT | SUV39H2 | ENSBTAP00000043450 | ENSBTAP00000013472 | Calmodulin-lysine N-methyltransferase. | Histone-lysine N-methyltransferase SUV39H2; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric re [...] | 0.683 |
DOT1L | CAMKMT | ENSBTAP00000065258 | ENSBTAP00000043450 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | Calmodulin-lysine N-methyltransferase. | 0.746 |
DOT1L | HIST1H3C | ENSBTAP00000065258 | ENSBTAP00000059273 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | Histone H3.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.944 |
DOT1L | KMT5A | ENSBTAP00000065258 | ENSBTAP00000055591 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | N-lysine methyltransferase KMT5A; Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper [...] | 0.637 |
DOT1L | LOC788077 | ENSBTAP00000065258 | ENSBTAP00000062977 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | Histone H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.944 |
DOT1L | PLOD1 | ENSBTAP00000065258 | ENSBTAP00000002658 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1; Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys- Gly- sequences in collagens (By similarity). These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (By similarity). | 0.650 |
DOT1L | PLOD3 | ENSBTAP00000065258 | ENSBTAP00000000447 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3. | 0.650 |
DOT1L | SETD7 | ENSBTAP00000065258 | ENSBTAP00000004658 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. | 0.597 |
DOT1L | SMYD2 | ENSBTAP00000065258 | ENSBTAP00000017516 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | N-lysine methyltransferase SMYD2; Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'. | 0.730 |
DOT1L | SUV39H2 | ENSBTAP00000065258 | ENSBTAP00000013472 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | Histone-lysine N-methyltransferase SUV39H2; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric re [...] | 0.586 |
HIST1H3C | DOT1L | ENSBTAP00000059273 | ENSBTAP00000065258 | Histone H3.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | 0.944 |
HIST1H3C | KMT5A | ENSBTAP00000059273 | ENSBTAP00000055591 | Histone H3.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | N-lysine methyltransferase KMT5A; Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper [...] | 0.718 |
HIST1H3C | LOC788077 | ENSBTAP00000059273 | ENSBTAP00000062977 | Histone H3.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | Histone H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.969 |
HIST1H3C | SETD7 | ENSBTAP00000059273 | ENSBTAP00000004658 | Histone H3.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. | 0.714 |