STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CATHL5Cathelicidin-5; Exerts a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, and fungi; Belongs to the cathelicidin family. (244 aa)    
Predicted Functional Partners:
NFKB1
Nuclear factor kappa B subunit 1.
   
 
 0.906
RELA
V-rel reticuloendotheliosis viral oncogene homolog A (Avian).
   
 
 0.904
JUN
Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28. Binds to the USP28 promoter; Belongs to the bZIP family. Jun subfamily.
     
 0.901
LAP
Lingual antimicrobial peptide; Shows a broad spectrum of antibacterial and antifungal activities; Belongs to the beta-defensin family. LAP/TAP subfamily.
   
  
 0.756
TAP
Tracheal antimicrobial peptide; Has antibacterial activity in vitro against Escherichia coli, Staphylococcus aureus, Klebsiella pneumonia, and Pseudomonas aeruginosa. In addition, the peptide is active against Candida albicans, indicating a broad spectrum of activity.
   
  
 0.750
DEFB10
Beta-defensin 10; Has bactericidal activity. Active against E.coli ML35 and S.aureus 502A.
   
  
 0.691
EBD
Enteric beta-defensin; Has antibacterial activity.
   
  
 0.662
DEFB1
Beta-defensin 1; Has bactericidal activity. Active against E.coli ML35 but not against S.aureus 502A. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (By similarity); Belongs to the beta-defensin family.
   
  
 0.659
DEFB13
Beta-defensin 11; Has bactericidal activity. Active against E.coli ML35 and S.aureus 502A.
   
  
 0.644
LTF
Lactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Lactoferricin B is an antimicrobial peptide. Inhibits the growth of Gram-negative and Gram-positive bacteria.
   
  
 0.642
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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