node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHMP1A | CHMP2A | ENSBTAP00000044604 | ENSBTAP00000018429 | Charged multivesicular body protein 1A. | Charged multivesicular body protein 2A. | 0.999 |
CHMP1A | CHMP3 | ENSBTAP00000044604 | ENSBTAP00000068505 | Charged multivesicular body protein 1A. | Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...] | 0.996 |
CHMP1A | CHMP4B | ENSBTAP00000044604 | ENSBTAP00000017812 | Charged multivesicular body protein 1A. | Charged multivesicular body protein 4B. | 0.904 |
CHMP1A | CHMP4C | ENSBTAP00000044604 | ENSBTAP00000006291 | Charged multivesicular body protein 1A. | Charged multivesicular body protein 4C. | 0.980 |
CHMP1A | CHMP5 | ENSBTAP00000044604 | ENSBTAP00000016431 | Charged multivesicular body protein 1A. | Charged multivesicular body protein 5. | 0.984 |
CHMP1A | CHMP6 | ENSBTAP00000044604 | ENSBTAP00000018623 | Charged multivesicular body protein 1A. | Charged multivesicular body protein 6. | 0.942 |
CHMP1A | CHMP7 | ENSBTAP00000044604 | ENSBTAP00000017987 | Charged multivesicular body protein 1A. | Charged multivesicular body protein 7. | 0.888 |
CHMP1A | IST1 | ENSBTAP00000044604 | ENSBTAP00000032246 | Charged multivesicular body protein 1A. | IST1 homolog; ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Regulates early endosomal tubulation together wi [...] | 0.996 |
CHMP1A | VPS36 | ENSBTAP00000044604 | ENSBTAP00000005646 | Charged multivesicular body protein 1A. | Vacuolar protein-sorting-associated protein 36; Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may a [...] | 0.790 |
CHMP1A | VPS4A | ENSBTAP00000044604 | ENSBTAP00000055660 | Charged multivesicular body protein 1A. | Uncharacterized protein; Belongs to the AAA ATPase family. | 0.996 |
CHMP2A | CHMP1A | ENSBTAP00000018429 | ENSBTAP00000044604 | Charged multivesicular body protein 2A. | Charged multivesicular body protein 1A. | 0.999 |
CHMP2A | CHMP3 | ENSBTAP00000018429 | ENSBTAP00000068505 | Charged multivesicular body protein 2A. | Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...] | 0.986 |
CHMP2A | CHMP4B | ENSBTAP00000018429 | ENSBTAP00000017812 | Charged multivesicular body protein 2A. | Charged multivesicular body protein 4B. | 0.959 |
CHMP2A | CHMP4C | ENSBTAP00000018429 | ENSBTAP00000006291 | Charged multivesicular body protein 2A. | Charged multivesicular body protein 4C. | 0.980 |
CHMP2A | CHMP5 | ENSBTAP00000018429 | ENSBTAP00000016431 | Charged multivesicular body protein 2A. | Charged multivesicular body protein 5. | 0.985 |
CHMP2A | CHMP6 | ENSBTAP00000018429 | ENSBTAP00000018623 | Charged multivesicular body protein 2A. | Charged multivesicular body protein 6. | 0.981 |
CHMP2A | CHMP7 | ENSBTAP00000018429 | ENSBTAP00000017987 | Charged multivesicular body protein 2A. | Charged multivesicular body protein 7. | 0.940 |
CHMP2A | IST1 | ENSBTAP00000018429 | ENSBTAP00000032246 | Charged multivesicular body protein 2A. | IST1 homolog; ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Regulates early endosomal tubulation together wi [...] | 0.974 |
CHMP2A | VPS36 | ENSBTAP00000018429 | ENSBTAP00000005646 | Charged multivesicular body protein 2A. | Vacuolar protein-sorting-associated protein 36; Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may a [...] | 0.880 |
CHMP2A | VPS4A | ENSBTAP00000018429 | ENSBTAP00000055660 | Charged multivesicular body protein 2A. | Uncharacterized protein; Belongs to the AAA ATPase family. | 0.976 |