node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATL1 | NIPA1 | ENSBTAP00000019032 | ENSBTAP00000002985 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. | NIPA magnesium transporter 1. | 0.770 |
ATL1 | REEP1 | ENSBTAP00000019032 | ENSBTAP00000064769 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. | Receptor expression-enhancing protein. | 0.957 |
ATL1 | REEP2 | ENSBTAP00000019032 | ENSBTAP00000056961 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. | Receptor expression-enhancing protein 2; Required for endoplasmic reticulum (ER) network formation, shaping and remodeling. May enhance the cell surface expression of odorant receptors (By similarity). | 0.793 |
ATL1 | REEP3 | ENSBTAP00000019032 | ENSBTAP00000056822 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. | Receptor expression-enhancing protein. | 0.762 |
ATL1 | REEP4 | ENSBTAP00000019032 | ENSBTAP00000068957 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. | Receptor expression-enhancing protein 4; Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes (By similarity); Belongs to the DP1 family. | 0.767 |
ATL1 | RTN2 | ENSBTAP00000019032 | ENSBTAP00000010770 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. | Reticulon. | 0.916 |
ATL1 | RTN4 | ENSBTAP00000019032 | ENSBTAP00000014745 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. | Reticulon. | 0.807 |
ATL1 | SPART | ENSBTAP00000019032 | ENSBTAP00000010577 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. | Spartin; May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis. | 0.839 |
ATL1 | SPAST | ENSBTAP00000019032 | ENSBTAP00000044166 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. | Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] | 0.946 |
ATL1 | ZFYVE27 | ENSBTAP00000019032 | ENSBTAP00000071500 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. | Protrudin; Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity. Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections. Acts as an adapter protein that facilitates the interaction of KIF5A with VAPA, VAPB, [...] | 0.746 |
NIPA1 | ATL1 | ENSBTAP00000002985 | ENSBTAP00000019032 | NIPA magnesium transporter 1. | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. | 0.770 |
NIPA1 | REEP1 | ENSBTAP00000002985 | ENSBTAP00000064769 | NIPA magnesium transporter 1. | Receptor expression-enhancing protein. | 0.829 |
NIPA1 | REEP2 | ENSBTAP00000002985 | ENSBTAP00000056961 | NIPA magnesium transporter 1. | Receptor expression-enhancing protein 2; Required for endoplasmic reticulum (ER) network formation, shaping and remodeling. May enhance the cell surface expression of odorant receptors (By similarity). | 0.431 |
NIPA1 | RTN2 | ENSBTAP00000002985 | ENSBTAP00000010770 | NIPA magnesium transporter 1. | Reticulon. | 0.638 |
NIPA1 | SPART | ENSBTAP00000002985 | ENSBTAP00000010577 | NIPA magnesium transporter 1. | Spartin; May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis. | 0.852 |
NIPA1 | SPAST | ENSBTAP00000002985 | ENSBTAP00000044166 | NIPA magnesium transporter 1. | Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] | 0.791 |
NIPA1 | ZFYVE27 | ENSBTAP00000002985 | ENSBTAP00000071500 | NIPA magnesium transporter 1. | Protrudin; Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity. Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections. Acts as an adapter protein that facilitates the interaction of KIF5A with VAPA, VAPB, [...] | 0.629 |
REEP1 | ATL1 | ENSBTAP00000064769 | ENSBTAP00000019032 | Receptor expression-enhancing protein. | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. | 0.957 |
REEP1 | NIPA1 | ENSBTAP00000064769 | ENSBTAP00000002985 | Receptor expression-enhancing protein. | NIPA magnesium transporter 1. | 0.829 |
REEP1 | REEP2 | ENSBTAP00000064769 | ENSBTAP00000056961 | Receptor expression-enhancing protein. | Receptor expression-enhancing protein 2; Required for endoplasmic reticulum (ER) network formation, shaping and remodeling. May enhance the cell surface expression of odorant receptors (By similarity). | 0.679 |