node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DDX58 | IFI44 | ENSBTAP00000053514 | ENSBTAP00000062052 | DExD/H-box helicase 58. | Interferon induced protein 44. | 0.923 |
DDX58 | IFIT1 | ENSBTAP00000053514 | ENSBTAP00000010366 | DExD/H-box helicase 58. | Interferon induced protein with tetratricopeptide repeats 1. | 0.968 |
DDX58 | IFIT2 | ENSBTAP00000053514 | ENSBTAP00000048821 | DExD/H-box helicase 58. | Interferon induced protein with tetratricopeptide repeats 2. | 0.920 |
DDX58 | ISG15 | ENSBTAP00000053514 | ENSBTAP00000019573 | DExD/H-box helicase 58. | Ubiquitin-like protein ISG15; Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein. Exhibits antiviral activity towards both DNA and RNA viruses. The secreted form of ISG15 can: induce natural killer cell proliferation, augment lymphokine-activated- killer (LAK) activi [...] | 0.994 |
DDX58 | MX1 | ENSBTAP00000053514 | ENSBTAP00000041289 | DExD/H-box helicase 58. | Interferon-induced GTP-binding protein Mx1; Interferon-induced dynamin-like GTPase with antiviral activity against rabies virus (RABV), vesicular stomatitis virus (VSV) and murine pneumonia virus (MPV). Isoform 1 but not isoform 2 shows antiviral activity against vesicular stomatitis virus (VSV). Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | 0.935 |
DDX58 | MX2 | ENSBTAP00000053514 | ENSBTAP00000011146 | DExD/H-box helicase 58. | Interferon-induced GTP-binding protein Mx2; Interferon-induced dynamin-like GTPase with antiviral activity against vesicular stomatitis virus (VSV). | 0.894 |
DDX58 | OAS2 | ENSBTAP00000053514 | ENSBTAP00000019477 | DExD/H-box helicase 58. | 2'-5'-oligoadenylate synthase 2; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation. Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antivir [...] | 0.831 |
DDX58 | RNASEL | ENSBTAP00000053514 | ENSBTAP00000041757 | DExD/H-box helicase 58. | Ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent). | 0.653 |
DDX58 | RSAD2 | ENSBTAP00000053514 | ENSBTAP00000021373 | DExD/H-box helicase 58. | Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of viruses, including west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus and vesicular stomatitis virus (VSV). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, thro [...] | 0.943 |
DDX58 | STAT1 | ENSBTAP00000053514 | ENSBTAP00000067158 | DExD/H-box helicase 58. | Signal transducer and activator of transcription. | 0.976 |
IFI44 | DDX58 | ENSBTAP00000062052 | ENSBTAP00000053514 | Interferon induced protein 44. | DExD/H-box helicase 58. | 0.923 |
IFI44 | IFIT1 | ENSBTAP00000062052 | ENSBTAP00000010366 | Interferon induced protein 44. | Interferon induced protein with tetratricopeptide repeats 1. | 0.913 |
IFI44 | IFIT2 | ENSBTAP00000062052 | ENSBTAP00000048821 | Interferon induced protein 44. | Interferon induced protein with tetratricopeptide repeats 2. | 0.878 |
IFI44 | ISG15 | ENSBTAP00000062052 | ENSBTAP00000019573 | Interferon induced protein 44. | Ubiquitin-like protein ISG15; Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein. Exhibits antiviral activity towards both DNA and RNA viruses. The secreted form of ISG15 can: induce natural killer cell proliferation, augment lymphokine-activated- killer (LAK) activi [...] | 0.952 |
IFI44 | MX1 | ENSBTAP00000062052 | ENSBTAP00000041289 | Interferon induced protein 44. | Interferon-induced GTP-binding protein Mx1; Interferon-induced dynamin-like GTPase with antiviral activity against rabies virus (RABV), vesicular stomatitis virus (VSV) and murine pneumonia virus (MPV). Isoform 1 but not isoform 2 shows antiviral activity against vesicular stomatitis virus (VSV). Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | 0.873 |
IFI44 | MX2 | ENSBTAP00000062052 | ENSBTAP00000011146 | Interferon induced protein 44. | Interferon-induced GTP-binding protein Mx2; Interferon-induced dynamin-like GTPase with antiviral activity against vesicular stomatitis virus (VSV). | 0.868 |
IFI44 | OAS2 | ENSBTAP00000062052 | ENSBTAP00000019477 | Interferon induced protein 44. | 2'-5'-oligoadenylate synthase 2; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation. Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antivir [...] | 0.830 |
IFI44 | RNASEL | ENSBTAP00000062052 | ENSBTAP00000041757 | Interferon induced protein 44. | Ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent). | 0.512 |
IFI44 | RSAD2 | ENSBTAP00000062052 | ENSBTAP00000021373 | Interferon induced protein 44. | Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of viruses, including west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus and vesicular stomatitis virus (VSV). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, thro [...] | 0.976 |
IFI44 | STAT1 | ENSBTAP00000062052 | ENSBTAP00000067158 | Interferon induced protein 44. | Signal transducer and activator of transcription. | 0.865 |