node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AP2S1 | TBCB | ENSBTAP00000074109 | ENSBTAP00000019973 | AP-2 complex subunit sigma; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | Tubulin-folding cofactor B; Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth. | 0.703 |
ARL2 | TBCB | ENSBTAP00000002890 | ENSBTAP00000019973 | ADP-ribosylation factor-like protein 2; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the ef [...] | Tubulin-folding cofactor B; Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth. | 0.758 |
ARL2 | TBCC | ENSBTAP00000002890 | ENSBTAP00000001245 | ADP-ribosylation factor-like protein 2; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the ef [...] | Tubulin-specific chaperone C; Tubulin-folding protein; involved in the final step of the tubulin folding pathway. | 0.455 |
ARL2 | TBCD | ENSBTAP00000002890 | ENSBTAP00000065270 | ADP-ribosylation factor-like protein 2; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the ef [...] | Tubulin-specific chaperone D; Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP- bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes ep [...] | 0.987 |
ARL2 | TBCE | ENSBTAP00000002890 | ENSBTAP00000018249 | ADP-ribosylation factor-like protein 2; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the ef [...] | Tubulin-specific chaperone E; Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network. | 0.750 |
CADM2 | GPATCH4 | ENSBTAP00000012150 | ENSBTAP00000065937 | Cell adhesion molecule 2. | G patch domain-containing protein 4. | 0.781 |
CADM2 | TBCB | ENSBTAP00000012150 | ENSBTAP00000019973 | Cell adhesion molecule 2. | Tubulin-folding cofactor B; Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth. | 0.677 |
ENSBTAP00000064088 | TBCB | ENSBTAP00000064088 | ENSBTAP00000019973 | Tubulin-specific chaperone A; Belongs to the TBCA family. | Tubulin-folding cofactor B; Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth. | 0.767 |
ENSBTAP00000064088 | TBCC | ENSBTAP00000064088 | ENSBTAP00000001245 | Tubulin-specific chaperone A; Belongs to the TBCA family. | Tubulin-specific chaperone C; Tubulin-folding protein; involved in the final step of the tubulin folding pathway. | 0.433 |
ENSBTAP00000064088 | TBCD | ENSBTAP00000064088 | ENSBTAP00000065270 | Tubulin-specific chaperone A; Belongs to the TBCA family. | Tubulin-specific chaperone D; Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP- bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes ep [...] | 0.432 |
ENSBTAP00000064088 | TBCE | ENSBTAP00000064088 | ENSBTAP00000018249 | Tubulin-specific chaperone A; Belongs to the TBCA family. | Tubulin-specific chaperone E; Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network. | 0.811 |
ENSBTAP00000064088 | TBCEL | ENSBTAP00000064088 | ENSBTAP00000024242 | Tubulin-specific chaperone A; Belongs to the TBCA family. | Tubulin folding cofactor E like. | 0.431 |
GPATCH4 | CADM2 | ENSBTAP00000065937 | ENSBTAP00000012150 | G patch domain-containing protein 4. | Cell adhesion molecule 2. | 0.781 |
GPATCH4 | TBCB | ENSBTAP00000065937 | ENSBTAP00000019973 | G patch domain-containing protein 4. | Tubulin-folding cofactor B; Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth. | 0.724 |
TBCA | TBCB | ENSBTAP00000004227 | ENSBTAP00000019973 | Tubulin-specific chaperone A; Tubulin-folding protein; involved in the early step of the tubulin folding pathway; Belongs to the TBCA family. | Tubulin-folding cofactor B; Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth. | 0.808 |
TBCA | TBCC | ENSBTAP00000004227 | ENSBTAP00000001245 | Tubulin-specific chaperone A; Tubulin-folding protein; involved in the early step of the tubulin folding pathway; Belongs to the TBCA family. | Tubulin-specific chaperone C; Tubulin-folding protein; involved in the final step of the tubulin folding pathway. | 0.745 |
TBCA | TBCD | ENSBTAP00000004227 | ENSBTAP00000065270 | Tubulin-specific chaperone A; Tubulin-folding protein; involved in the early step of the tubulin folding pathway; Belongs to the TBCA family. | Tubulin-specific chaperone D; Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP- bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes ep [...] | 0.745 |
TBCA | TBCE | ENSBTAP00000004227 | ENSBTAP00000018249 | Tubulin-specific chaperone A; Tubulin-folding protein; involved in the early step of the tubulin folding pathway; Belongs to the TBCA family. | Tubulin-specific chaperone E; Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network. | 0.864 |
TBCA | TBCEL | ENSBTAP00000004227 | ENSBTAP00000024242 | Tubulin-specific chaperone A; Tubulin-folding protein; involved in the early step of the tubulin folding pathway; Belongs to the TBCA family. | Tubulin folding cofactor E like. | 0.797 |
TBCB | AP2S1 | ENSBTAP00000019973 | ENSBTAP00000074109 | Tubulin-folding cofactor B; Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth. | AP-2 complex subunit sigma; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | 0.703 |