node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSBTAP00000061428 | ENSBTAP00000073746 | ENSBTAP00000061428 | ENSBTAP00000073746 | Uncharacterized protein. | Uncharacterized protein. | 0.552 |
ENSBTAP00000061428 | G3N2K6_BOVIN | ENSBTAP00000061428 | ENSBTAP00000056121 | Uncharacterized protein. | Uncharacterized protein. | 0.555 |
ENSBTAP00000061428 | LAMTOR1 | ENSBTAP00000061428 | ENSBTAP00000059517 | Uncharacterized protein. | Ragulator complex protein LAMTOR1; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulat [...] | 0.882 |
ENSBTAP00000061428 | LAMTOR2 | ENSBTAP00000061428 | ENSBTAP00000045185 | Uncharacterized protein. | Ragulator complex protein LAMTOR2; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP k [...] | 0.896 |
ENSBTAP00000061428 | LAMTOR3 | ENSBTAP00000061428 | ENSBTAP00000044998 | Uncharacterized protein. | Ragulator complex protein LAMTOR3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP k [...] | 0.891 |
ENSBTAP00000061428 | LAMTOR4 | ENSBTAP00000061428 | ENSBTAP00000019980 | Uncharacterized protein. | Ragulator complex protein LAMTOR4, N-terminally processed; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (By similarity). | 0.890 |
ENSBTAP00000061428 | LAMTOR5 | ENSBTAP00000061428 | ENSBTAP00000019928 | Uncharacterized protein. | Ragulator complex protein LAMTOR5; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assem [...] | 0.549 |
ENSBTAP00000061428 | RPTOR | ENSBTAP00000061428 | ENSBTAP00000003739 | Uncharacterized protein. | Regulatory associated protein of MTOR complex 1. | 0.716 |
ENSBTAP00000061428 | RRAGA | ENSBTAP00000061428 | ENSBTAP00000051093 | Uncharacterized protein. | Ras-related GTP-binding protein A; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. | 0.546 |
ENSBTAP00000061428 | RRAGC | ENSBTAP00000061428 | ENSBTAP00000012331 | Uncharacterized protein. | Ras-related GTP binding C. | 0.627 |
ENSBTAP00000073746 | ENSBTAP00000061428 | ENSBTAP00000073746 | ENSBTAP00000061428 | Uncharacterized protein. | Uncharacterized protein. | 0.552 |
ENSBTAP00000073746 | G3N2K6_BOVIN | ENSBTAP00000073746 | ENSBTAP00000056121 | Uncharacterized protein. | Uncharacterized protein. | 0.547 |
ENSBTAP00000073746 | LAMTOR1 | ENSBTAP00000073746 | ENSBTAP00000059517 | Uncharacterized protein. | Ragulator complex protein LAMTOR1; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulat [...] | 0.882 |
ENSBTAP00000073746 | LAMTOR2 | ENSBTAP00000073746 | ENSBTAP00000045185 | Uncharacterized protein. | Ragulator complex protein LAMTOR2; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP k [...] | 0.896 |
ENSBTAP00000073746 | LAMTOR3 | ENSBTAP00000073746 | ENSBTAP00000044998 | Uncharacterized protein. | Ragulator complex protein LAMTOR3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP k [...] | 0.891 |
ENSBTAP00000073746 | LAMTOR4 | ENSBTAP00000073746 | ENSBTAP00000019980 | Uncharacterized protein. | Ragulator complex protein LAMTOR4, N-terminally processed; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (By similarity). | 0.890 |
ENSBTAP00000073746 | LAMTOR5 | ENSBTAP00000073746 | ENSBTAP00000019928 | Uncharacterized protein. | Ragulator complex protein LAMTOR5; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assem [...] | 0.544 |
ENSBTAP00000073746 | RPTOR | ENSBTAP00000073746 | ENSBTAP00000003739 | Uncharacterized protein. | Regulatory associated protein of MTOR complex 1. | 0.716 |
ENSBTAP00000073746 | RRAGA | ENSBTAP00000073746 | ENSBTAP00000051093 | Uncharacterized protein. | Ras-related GTP-binding protein A; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. | 0.546 |
ENSBTAP00000073746 | RRAGC | ENSBTAP00000073746 | ENSBTAP00000012331 | Uncharacterized protein. | Ras-related GTP binding C. | 0.627 |