node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
20ALPHA-HSD | HPGDS | ENSBTAP00000051595 | ENSBTAP00000022700 | Aldo_ket_red domain-containing protein. | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | 0.909 |
20ALPHA-HSD | LOC527068 | ENSBTAP00000051595 | ENSBTAP00000030543 | Aldo_ket_red domain-containing protein. | Aldo_ket_red domain-containing protein. | 0.405 |
20ALPHA-HSD | PTGDS | ENSBTAP00000051595 | ENSBTAP00000068174 | Aldo_ket_red domain-containing protein. | Prostaglandin-H2 D-isomerase; Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possib [...] | 0.932 |
20ALPHA-HSD | PTGES2 | ENSBTAP00000051595 | ENSBTAP00000056972 | Aldo_ket_red domain-containing protein. | Prostaglandin E synthase 2 truncated form; Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2); Belongs to the GST superfamily. | 0.465 |
HPGDS | 20ALPHA-HSD | ENSBTAP00000022700 | ENSBTAP00000051595 | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | Aldo_ket_red domain-containing protein. | 0.909 |
HPGDS | LOC112449293 | ENSBTAP00000022700 | ENSBTAP00000023853 | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | Aldo_ket_red domain-containing protein. | 0.909 |
HPGDS | LOC527068 | ENSBTAP00000022700 | ENSBTAP00000030543 | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | Aldo_ket_red domain-containing protein. | 0.909 |
HPGDS | PTGDS | ENSBTAP00000022700 | ENSBTAP00000068174 | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | Prostaglandin-H2 D-isomerase; Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possib [...] | 0.975 |
HPGDS | PTGES | ENSBTAP00000022700 | ENSBTAP00000025912 | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | Prostaglandin E synthase; Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). | 0.961 |
HPGDS | PTGES2 | ENSBTAP00000022700 | ENSBTAP00000056972 | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | Prostaglandin E synthase 2 truncated form; Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2); Belongs to the GST superfamily. | 0.952 |
HPGDS | PTGES3 | ENSBTAP00000022700 | ENSBTAP00000023908 | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | Prostaglandin E synthase 3; Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway. | 0.951 |
HPGDS | PTGIS | ENSBTAP00000022700 | ENSBTAP00000057920 | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | Prostacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. | 0.941 |
HPGDS | PTGS1 | ENSBTAP00000022700 | ENSBTAP00000008833 | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | Prostaglandin G/H synthase 1; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells (By similarity). | 0.962 |
HPGDS | PTGS2 | ENSBTAP00000022700 | ENSBTAP00000018774 | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] | 0.946 |
LOC112449293 | HPGDS | ENSBTAP00000023853 | ENSBTAP00000022700 | Aldo_ket_red domain-containing protein. | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | 0.909 |
LOC112449293 | PTGDS | ENSBTAP00000023853 | ENSBTAP00000068174 | Aldo_ket_red domain-containing protein. | Prostaglandin-H2 D-isomerase; Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possib [...] | 0.932 |
LOC112449293 | PTGES2 | ENSBTAP00000023853 | ENSBTAP00000056972 | Aldo_ket_red domain-containing protein. | Prostaglandin E synthase 2 truncated form; Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2); Belongs to the GST superfamily. | 0.465 |
LOC527068 | 20ALPHA-HSD | ENSBTAP00000030543 | ENSBTAP00000051595 | Aldo_ket_red domain-containing protein. | Aldo_ket_red domain-containing protein. | 0.405 |
LOC527068 | HPGDS | ENSBTAP00000030543 | ENSBTAP00000022700 | Aldo_ket_red domain-containing protein. | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | 0.909 |
LOC527068 | PTGDS | ENSBTAP00000030543 | ENSBTAP00000068174 | Aldo_ket_red domain-containing protein. | Prostaglandin-H2 D-isomerase; Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possib [...] | 0.932 |