node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CUL1 | ENSBTAP00000057099 | ENSBTAP00000063991 | ENSBTAP00000057099 | Cullin 1; Belongs to the cullin family. | Skp1_POZ domain-containing protein; Belongs to the SKP1 family. | 0.531 |
CUL1 | ENSBTAP00000069011 | ENSBTAP00000063991 | ENSBTAP00000069011 | Cullin 1; Belongs to the cullin family. | Skp1_POZ domain-containing protein; Belongs to the SKP1 family. | 0.531 |
CUL1 | ENSBTAP00000072193 | ENSBTAP00000063991 | ENSBTAP00000072193 | Cullin 1; Belongs to the cullin family. | Skp1_POZ domain-containing protein; Belongs to the SKP1 family. | 0.531 |
CUL1 | ENSBTAP00000072606 | ENSBTAP00000063991 | ENSBTAP00000072606 | Cullin 1; Belongs to the cullin family. | Uncharacterized protein; Belongs to the SKP1 family. | 0.531 |
CUL1 | FBXO4 | ENSBTAP00000063991 | ENSBTAP00000022583 | Cullin 1; Belongs to the cullin family. | F-box only protein 4; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (By similarity). | 0.881 |
CUL1 | FBXO9 | ENSBTAP00000063991 | ENSBTAP00000020074 | Cullin 1; Belongs to the cullin family. | F-box only protein 9; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTOR [...] | 0.918 |
CUL1 | SKP1 | ENSBTAP00000063991 | ENSBTAP00000035184 | Cullin 1; Belongs to the cullin family. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.999 |
ENSBTAP00000057099 | CUL1 | ENSBTAP00000057099 | ENSBTAP00000063991 | Skp1_POZ domain-containing protein; Belongs to the SKP1 family. | Cullin 1; Belongs to the cullin family. | 0.531 |
ENSBTAP00000057099 | FBXO4 | ENSBTAP00000057099 | ENSBTAP00000022583 | Skp1_POZ domain-containing protein; Belongs to the SKP1 family. | F-box only protein 4; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (By similarity). | 0.660 |
ENSBTAP00000057099 | FBXO9 | ENSBTAP00000057099 | ENSBTAP00000020074 | Skp1_POZ domain-containing protein; Belongs to the SKP1 family. | F-box only protein 9; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTOR [...] | 0.668 |
ENSBTAP00000069011 | CUL1 | ENSBTAP00000069011 | ENSBTAP00000063991 | Skp1_POZ domain-containing protein; Belongs to the SKP1 family. | Cullin 1; Belongs to the cullin family. | 0.531 |
ENSBTAP00000069011 | FBXO4 | ENSBTAP00000069011 | ENSBTAP00000022583 | Skp1_POZ domain-containing protein; Belongs to the SKP1 family. | F-box only protein 4; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (By similarity). | 0.660 |
ENSBTAP00000069011 | FBXO9 | ENSBTAP00000069011 | ENSBTAP00000020074 | Skp1_POZ domain-containing protein; Belongs to the SKP1 family. | F-box only protein 9; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTOR [...] | 0.668 |
ENSBTAP00000072193 | CUL1 | ENSBTAP00000072193 | ENSBTAP00000063991 | Skp1_POZ domain-containing protein; Belongs to the SKP1 family. | Cullin 1; Belongs to the cullin family. | 0.531 |
ENSBTAP00000072193 | FBXO4 | ENSBTAP00000072193 | ENSBTAP00000022583 | Skp1_POZ domain-containing protein; Belongs to the SKP1 family. | F-box only protein 4; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (By similarity). | 0.660 |
ENSBTAP00000072193 | FBXO9 | ENSBTAP00000072193 | ENSBTAP00000020074 | Skp1_POZ domain-containing protein; Belongs to the SKP1 family. | F-box only protein 9; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTOR [...] | 0.668 |
ENSBTAP00000072606 | CUL1 | ENSBTAP00000072606 | ENSBTAP00000063991 | Uncharacterized protein; Belongs to the SKP1 family. | Cullin 1; Belongs to the cullin family. | 0.531 |
ENSBTAP00000072606 | FBXO4 | ENSBTAP00000072606 | ENSBTAP00000022583 | Uncharacterized protein; Belongs to the SKP1 family. | F-box only protein 4; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (By similarity). | 0.660 |
ENSBTAP00000072606 | FBXO9 | ENSBTAP00000072606 | ENSBTAP00000020074 | Uncharacterized protein; Belongs to the SKP1 family. | F-box only protein 9; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTOR [...] | 0.668 |
FBXO4 | CUL1 | ENSBTAP00000022583 | ENSBTAP00000063991 | F-box only protein 4; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (By similarity). | Cullin 1; Belongs to the cullin family. | 0.881 |