node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCL19 | CCL21 | ENSBTAP00000016850 | ENSBTAP00000033580 | C-C motif chemokine. | C-C motif chemokine ligand 21. | 0.982 |
CCL19 | CCL25 | ENSBTAP00000016850 | ENSBTAP00000007331 | C-C motif chemokine. | C-C motif chemokine ligand 25. | 0.907 |
CCL19 | CCL5 | ENSBTAP00000016850 | ENSBTAP00000057122 | C-C motif chemokine. | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | 0.651 |
CCL19 | CXCL10 | ENSBTAP00000016850 | ENSBTAP00000039324 | C-C motif chemokine. | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] | 0.875 |
CCL19 | CXCL12 | ENSBTAP00000016850 | ENSBTAP00000066613 | C-C motif chemokine. | C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. | 0.950 |
CCL19 | CXCL13 | ENSBTAP00000016850 | ENSBTAP00000011164 | C-C motif chemokine. | C-X-C motif chemokine. | 0.963 |
CCL19 | CXCL16 | ENSBTAP00000016850 | ENSBTAP00000024371 | C-C motif chemokine. | C-X-C motif chemokine 16; Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. Also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). | 0.803 |
CCL19 | CXCL9 | ENSBTAP00000016850 | ENSBTAP00000057632 | C-C motif chemokine. | C-X-C motif chemokine 9; Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3 (By similarity). Belongs to the intercrine alpha (chemokine CxC) family. | 0.894 |
CCL19 | CXCR6 | ENSBTAP00000016850 | ENSBTAP00000020855 | C-C motif chemokine. | G protein-coupled receptor TYMSTR; Belongs to the G-protein coupled receptor 1 family. | 0.882 |
CCL21 | CCL19 | ENSBTAP00000033580 | ENSBTAP00000016850 | C-C motif chemokine ligand 21. | C-C motif chemokine. | 0.982 |
CCL21 | CCL25 | ENSBTAP00000033580 | ENSBTAP00000007331 | C-C motif chemokine ligand 21. | C-C motif chemokine ligand 25. | 0.906 |
CCL21 | CCL5 | ENSBTAP00000033580 | ENSBTAP00000057122 | C-C motif chemokine ligand 21. | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | 0.993 |
CCL21 | CXCL10 | ENSBTAP00000033580 | ENSBTAP00000039324 | C-C motif chemokine ligand 21. | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] | 0.990 |
CCL21 | CXCL12 | ENSBTAP00000033580 | ENSBTAP00000066613 | C-C motif chemokine ligand 21. | C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. | 0.996 |
CCL21 | CXCL13 | ENSBTAP00000033580 | ENSBTAP00000011164 | C-C motif chemokine ligand 21. | C-X-C motif chemokine. | 0.988 |
CCL21 | CXCL16 | ENSBTAP00000033580 | ENSBTAP00000024371 | C-C motif chemokine ligand 21. | C-X-C motif chemokine 16; Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. Also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). | 0.778 |
CCL21 | CXCL9 | ENSBTAP00000033580 | ENSBTAP00000057632 | C-C motif chemokine ligand 21. | C-X-C motif chemokine 9; Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3 (By similarity). Belongs to the intercrine alpha (chemokine CxC) family. | 0.990 |
CCL21 | CXCR6 | ENSBTAP00000033580 | ENSBTAP00000020855 | C-C motif chemokine ligand 21. | G protein-coupled receptor TYMSTR; Belongs to the G-protein coupled receptor 1 family. | 0.886 |
CCL25 | CCL19 | ENSBTAP00000007331 | ENSBTAP00000016850 | C-C motif chemokine ligand 25. | C-C motif chemokine. | 0.907 |
CCL25 | CCL21 | ENSBTAP00000007331 | ENSBTAP00000033580 | C-C motif chemokine ligand 25. | C-C motif chemokine ligand 21. | 0.906 |