node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DLL1 | HEY1 | ENSBTAP00000067364 | ENSBTAP00000020864 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...] | 0.831 |
DLL1 | HEY2 | ENSBTAP00000067364 | ENSBTAP00000001214 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Hes related family bHLH transcription factor with YRPW motif 2. | 0.709 |
DLL1 | HEYL | ENSBTAP00000067364 | ENSBTAP00000011453 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Hairy/enhancer-of-split related with YRPW motif-like protein; Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6; Belongs to the HEY family. | 0.672 |
DLL1 | NOTCH1 | ENSBTAP00000067364 | ENSBTAP00000017746 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Notch receptor 1. | 0.994 |
DLL1 | NOTCH2 | ENSBTAP00000067364 | ENSBTAP00000073810 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Notch receptor 2. | 0.972 |
DLL1 | NOTCH3 | ENSBTAP00000067364 | ENSBTAP00000053357 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Notch receptor 3. | 0.969 |
DLL1 | NOTCH4 | ENSBTAP00000067364 | ENSBTAP00000046844 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Notch receptor 4. | 0.969 |
DLL1 | RBPJ | ENSBTAP00000067364 | ENSBTAP00000004696 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Recombining binding protein suppressor of hairless; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling [...] | 0.853 |
DLL4 | HEY1 | ENSBTAP00000013680 | ENSBTAP00000020864 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...] | 0.915 |
DLL4 | HEY2 | ENSBTAP00000013680 | ENSBTAP00000001214 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Hes related family bHLH transcription factor with YRPW motif 2. | 0.815 |
DLL4 | HEYL | ENSBTAP00000013680 | ENSBTAP00000011453 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Hairy/enhancer-of-split related with YRPW motif-like protein; Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6; Belongs to the HEY family. | 0.729 |
DLL4 | NOTCH1 | ENSBTAP00000013680 | ENSBTAP00000017746 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Notch receptor 1. | 0.999 |
DLL4 | NOTCH2 | ENSBTAP00000013680 | ENSBTAP00000073810 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Notch receptor 2. | 0.998 |
DLL4 | NOTCH3 | ENSBTAP00000013680 | ENSBTAP00000053357 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Notch receptor 3. | 0.997 |
DLL4 | NOTCH4 | ENSBTAP00000013680 | ENSBTAP00000046844 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Notch receptor 4. | 0.998 |
DLL4 | RBPJ | ENSBTAP00000013680 | ENSBTAP00000004696 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Recombining binding protein suppressor of hairless; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling [...] | 0.836 |
HEY1 | DLL1 | ENSBTAP00000020864 | ENSBTAP00000067364 | Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...] | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | 0.831 |
HEY1 | DLL4 | ENSBTAP00000020864 | ENSBTAP00000013680 | Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...] | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | 0.915 |
HEY1 | HEY2 | ENSBTAP00000020864 | ENSBTAP00000001214 | Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...] | Hes related family bHLH transcription factor with YRPW motif 2. | 0.905 |
HEY1 | HEYL | ENSBTAP00000020864 | ENSBTAP00000011453 | Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...] | Hairy/enhancer-of-split related with YRPW motif-like protein; Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6; Belongs to the HEY family. | 0.935 |