node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANOS1 | CHD7 | ENSBTAP00000001392 | ENSBTAP00000026607 | KAL1 protein. | Chromodomain helicase DNA binding protein 7. | 0.492 |
ANOS1 | HS6ST1 | ENSBTAP00000001392 | ENSBTAP00000058461 | KAL1 protein. | Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. | 0.636 |
ANOS1 | PROK1 | ENSBTAP00000001392 | ENSBTAP00000013959 | KAL1 protein. | Prokineticin 1. | 0.495 |
ANOS1 | PROK2 | ENSBTAP00000001392 | ENSBTAP00000025742 | KAL1 protein. | Prokineticin-2; May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle (By similarity). | 0.754 |
ANOS1 | PROKR2 | ENSBTAP00000001392 | ENSBTAP00000021097 | KAL1 protein. | Prokineticin receptor 2; Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase (By similarity). | 0.720 |
ANOS1 | TAC3 | ENSBTAP00000001392 | ENSBTAP00000029067 | KAL1 protein. | Neurokinin-B; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Is a critical central regulator of gonadal function (By similarity); Belongs to the tachykinin family. | 0.663 |
CHD7 | ANOS1 | ENSBTAP00000026607 | ENSBTAP00000001392 | Chromodomain helicase DNA binding protein 7. | KAL1 protein. | 0.492 |
CHD7 | HS6ST1 | ENSBTAP00000026607 | ENSBTAP00000058461 | Chromodomain helicase DNA binding protein 7. | Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. | 0.468 |
CHD7 | PROK2 | ENSBTAP00000026607 | ENSBTAP00000025742 | Chromodomain helicase DNA binding protein 7. | Prokineticin-2; May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle (By similarity). | 0.540 |
CHD7 | PROKR2 | ENSBTAP00000026607 | ENSBTAP00000021097 | Chromodomain helicase DNA binding protein 7. | Prokineticin receptor 2; Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase (By similarity). | 0.609 |
CHD7 | TAC3 | ENSBTAP00000026607 | ENSBTAP00000029067 | Chromodomain helicase DNA binding protein 7. | Neurokinin-B; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Is a critical central regulator of gonadal function (By similarity); Belongs to the tachykinin family. | 0.515 |
EDN1 | EDN3 | ENSBTAP00000010649 | ENSBTAP00000052537 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | EDN3 protein. | 0.932 |
EDN1 | GRP | ENSBTAP00000010649 | ENSBTAP00000070870 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Gastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity). | 0.582 |
EDN1 | PROK1 | ENSBTAP00000010649 | ENSBTAP00000013959 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Prokineticin 1. | 0.428 |
EDN1 | PROK2 | ENSBTAP00000010649 | ENSBTAP00000025742 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Prokineticin-2; May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle (By similarity). | 0.475 |
EDN1 | PROKR2 | ENSBTAP00000010649 | ENSBTAP00000021097 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Prokineticin receptor 2; Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase (By similarity). | 0.604 |
EDN1 | TAC3 | ENSBTAP00000010649 | ENSBTAP00000029067 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Neurokinin-B; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Is a critical central regulator of gonadal function (By similarity); Belongs to the tachykinin family. | 0.506 |
EDN3 | EDN1 | ENSBTAP00000052537 | ENSBTAP00000010649 | EDN3 protein. | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | 0.932 |
EDN3 | GRP | ENSBTAP00000052537 | ENSBTAP00000070870 | EDN3 protein. | Gastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity). | 0.505 |
EDN3 | PROK1 | ENSBTAP00000052537 | ENSBTAP00000013959 | EDN3 protein. | Prokineticin 1. | 0.571 |