node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COP1 | DET1 | ENSBTAP00000041946 | ENSBTAP00000001281 | COP1 E3 ubiquitin ligase. | DET1 partner of COP1 E3 ubiquitin ligase. | 0.980 |
COP1 | STK40 | ENSBTAP00000041946 | ENSBTAP00000061951 | COP1 E3 ubiquitin ligase. | Serine/threonine-protein kinase 40; May be a negative regulator of NF-kappa-B and p53-mediated gene transcription; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.736 |
COP1 | TRIB1 | ENSBTAP00000041946 | ENSBTAP00000031483 | COP1 E3 ubiquitin ligase. | Tribbles pseudokinase 1. | 0.835 |
COP1 | TRIB3 | ENSBTAP00000041946 | ENSBTAP00000022616 | COP1 E3 ubiquitin ligase. | Tribbles homolog 3; Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr- 308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activi [...] | 0.767 |
CTC1 | KPNA6 | ENSBTAP00000042139 | ENSBTAP00000003764 | CST telomere replication complex component 1. | Importin subunit alpha-7; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are [...] | 0.593 |
CTC1 | STK40 | ENSBTAP00000042139 | ENSBTAP00000061951 | CST telomere replication complex component 1. | Serine/threonine-protein kinase 40; May be a negative regulator of NF-kappa-B and p53-mediated gene transcription; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.628 |
CTC1 | VAC14 | ENSBTAP00000042139 | ENSBTAP00000032574 | CST telomere replication complex component 1. | Protein VAC14 homolog; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes (By similarity); Belongs to the VAC14 family. | 0.670 |
DET1 | COP1 | ENSBTAP00000001281 | ENSBTAP00000041946 | DET1 partner of COP1 E3 ubiquitin ligase. | COP1 E3 ubiquitin ligase. | 0.980 |
DET1 | STK40 | ENSBTAP00000001281 | ENSBTAP00000061951 | DET1 partner of COP1 E3 ubiquitin ligase. | Serine/threonine-protein kinase 40; May be a negative regulator of NF-kappa-B and p53-mediated gene transcription; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.678 |
DET1 | TRIB1 | ENSBTAP00000001281 | ENSBTAP00000031483 | DET1 partner of COP1 E3 ubiquitin ligase. | Tribbles pseudokinase 1. | 0.699 |
KPNA6 | CTC1 | ENSBTAP00000003764 | ENSBTAP00000042139 | Importin subunit alpha-7; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are [...] | CST telomere replication complex component 1. | 0.593 |
KPNA6 | STK40 | ENSBTAP00000003764 | ENSBTAP00000061951 | Importin subunit alpha-7; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are [...] | Serine/threonine-protein kinase 40; May be a negative regulator of NF-kappa-B and p53-mediated gene transcription; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.682 |
KPNA6 | VAC14 | ENSBTAP00000003764 | ENSBTAP00000032574 | Importin subunit alpha-7; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are [...] | Protein VAC14 homolog; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes (By similarity); Belongs to the VAC14 family. | 0.616 |
NLE1 | STK40 | ENSBTAP00000063224 | ENSBTAP00000061951 | Notchless protein homolog 1; Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity). | Serine/threonine-protein kinase 40; May be a negative regulator of NF-kappa-B and p53-mediated gene transcription; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.680 |
NLE1 | TTC28 | ENSBTAP00000063224 | ENSBTAP00000031582 | Notchless protein homolog 1; Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity). | Tetratricopeptide repeat domain 28. | 0.713 |
STK40 | COP1 | ENSBTAP00000061951 | ENSBTAP00000041946 | Serine/threonine-protein kinase 40; May be a negative regulator of NF-kappa-B and p53-mediated gene transcription; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | COP1 E3 ubiquitin ligase. | 0.736 |
STK40 | CTC1 | ENSBTAP00000061951 | ENSBTAP00000042139 | Serine/threonine-protein kinase 40; May be a negative regulator of NF-kappa-B and p53-mediated gene transcription; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | CST telomere replication complex component 1. | 0.628 |
STK40 | DET1 | ENSBTAP00000061951 | ENSBTAP00000001281 | Serine/threonine-protein kinase 40; May be a negative regulator of NF-kappa-B and p53-mediated gene transcription; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | DET1 partner of COP1 E3 ubiquitin ligase. | 0.678 |
STK40 | KPNA6 | ENSBTAP00000061951 | ENSBTAP00000003764 | Serine/threonine-protein kinase 40; May be a negative regulator of NF-kappa-B and p53-mediated gene transcription; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | Importin subunit alpha-7; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are [...] | 0.682 |
STK40 | NLE1 | ENSBTAP00000061951 | ENSBTAP00000063224 | Serine/threonine-protein kinase 40; May be a negative regulator of NF-kappa-B and p53-mediated gene transcription; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | Notchless protein homolog 1; Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity). | 0.680 |