STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PACSIN1Protein kinase C and casein kinase substrate in neurons protein 1; Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell corte [...] (459 aa)    
Predicted Functional Partners:
PACSIN3
Protein kinase C and casein kinase substrate in neurons 3.
  
 
0.871
PACSIN2
Protein kinase C and casein kinase substrate in neurons 2.
  
 
0.861
FCHO2
FCH domain only 2.
   
 
 0.763
FCHO1
FCH domain only 1.
   
 
 0.675
COBL
Cordon-bleu WH2 repeat protein.
    
 
 0.657
COBLL1
Cordon-bleu WH2 repeat protein like 1.
    
 
 0.641
FCHSD1
Uncharacterized protein.
    
 
 0.640
SPDEF
SAM pointed domain containing ETS transcription factor.
      
 0.639
ARHGEF37
Rho guanine nucleotide exchange factor 37.
      
 0.613
HMGA1
High mobility group AT-hook 1.
      
 0.606
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.