node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AK2 | DUSP26 | ENSBTAP00000023406 | ENSBTAP00000065349 | Adenylate kinase 2, mitochondrial, N-terminally processed; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.747 |
DUSP26 | AK2 | ENSBTAP00000065349 | ENSBTAP00000023406 | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Adenylate kinase 2, mitochondrial, N-terminally processed; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. | 0.747 |
DUSP26 | FAM124A | ENSBTAP00000065349 | ENSBTAP00000055257 | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Family with sequence similarity 124 member A. | 0.577 |
DUSP26 | HIKESHI | ENSBTAP00000065349 | ENSBTAP00000026632 | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Protein Hikeshi; Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin- dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus (By similarity). | 0.503 |
DUSP26 | PTPN3 | ENSBTAP00000065349 | ENSBTAP00000025085 | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. | 0.677 |
DUSP26 | RNF122 | ENSBTAP00000065349 | ENSBTAP00000021827 | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Ring finger protein 122. | 0.620 |
DUSP26 | SDSL | ENSBTAP00000065349 | ENSBTAP00000011776 | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Serine dehydratase like. | 0.575 |
DUSP26 | SERPINE3 | ENSBTAP00000065349 | ENSBTAP00000060825 | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Serpin E3; Probable serine protease inhibitor; Belongs to the serpin family. | 0.573 |
DUSP26 | ST6GALNAC5 | ENSBTAP00000065349 | ENSBTAP00000009616 | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; Belongs to the glycosyltransferase 29 family. | 0.546 |
DUSP26 | TTI2 | ENSBTAP00000065349 | ENSBTAP00000065777 | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | TELO2 interacting protein 2. | 0.545 |
DUSP26 | VSIR | ENSBTAP00000065349 | ENSBTAP00000066931 | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | V-set immunoregulatory receptor. | 0.533 |
FAM124A | DUSP26 | ENSBTAP00000055257 | ENSBTAP00000065349 | Family with sequence similarity 124 member A. | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.577 |
FAM124A | RNF122 | ENSBTAP00000055257 | ENSBTAP00000021827 | Family with sequence similarity 124 member A. | Ring finger protein 122. | 0.656 |
FAM124A | SERPINE3 | ENSBTAP00000055257 | ENSBTAP00000060825 | Family with sequence similarity 124 member A. | Serpin E3; Probable serine protease inhibitor; Belongs to the serpin family. | 0.701 |
FAM124A | ST6GALNAC5 | ENSBTAP00000055257 | ENSBTAP00000009616 | Family with sequence similarity 124 member A. | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; Belongs to the glycosyltransferase 29 family. | 0.576 |
HIKESHI | DUSP26 | ENSBTAP00000026632 | ENSBTAP00000065349 | Protein Hikeshi; Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin- dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus (By similarity). | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.503 |
HIKESHI | VSIR | ENSBTAP00000026632 | ENSBTAP00000066931 | Protein Hikeshi; Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin- dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus (By similarity). | V-set immunoregulatory receptor. | 0.496 |
PTPN3 | DUSP26 | ENSBTAP00000025085 | ENSBTAP00000065349 | Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.677 |
RNF122 | DUSP26 | ENSBTAP00000021827 | ENSBTAP00000065349 | Ring finger protein 122. | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.620 |
RNF122 | FAM124A | ENSBTAP00000021827 | ENSBTAP00000055257 | Ring finger protein 122. | Family with sequence similarity 124 member A. | 0.656 |