node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADCY3 | ADCY6 | ENSBTAP00000032877 | ENSBTAP00000007187 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | 0.918 |
ADCY3 | ADCY9 | ENSBTAP00000032877 | ENSBTAP00000059237 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | 0.935 |
ADCY3 | GNAO1 | ENSBTAP00000032877 | ENSBTAP00000033570 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Guanine nucleotide-binding protein G(o) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14 (By similarity). | 0.925 |
ADCY3 | GNAS | ENSBTAP00000032877 | ENSBTAP00000023246 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Neuroendocrine secretory protein 55; Belongs to the NESP55 family. | 0.900 |
ADCY3 | GNAS-2 | ENSBTAP00000032877 | ENSBTAP00000072381 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2 (By similarity). Belongs to the G-alpha family. G(s) subfamily. | 0.413 |
ADCY3 | NUDT2 | ENSBTAP00000032877 | ENSBTAP00000042493 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis. | 0.902 |
ADCY3 | PRKACA | ENSBTAP00000032877 | ENSBTAP00000063436 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] | 0.941 |
ADCY3 | PRKACB | ENSBTAP00000032877 | ENSBTAP00000046803 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, and differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these [...] | 0.943 |
ADCY3 | PRKCD | ENSBTAP00000032877 | ENSBTAP00000074537 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.903 |
ADCY3 | RAPGEF4 | ENSBTAP00000032877 | ENSBTAP00000053320 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Rap guanine nucleotide exchange factor 4. | 0.939 |
ADCY6 | ADCY3 | ENSBTAP00000007187 | ENSBTAP00000032877 | Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | 0.918 |
ADCY6 | ADCY9 | ENSBTAP00000007187 | ENSBTAP00000059237 | Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | 0.937 |
ADCY6 | GNAO1 | ENSBTAP00000007187 | ENSBTAP00000033570 | Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Guanine nucleotide-binding protein G(o) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14 (By similarity). | 0.925 |
ADCY6 | GNAS | ENSBTAP00000007187 | ENSBTAP00000023246 | Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Neuroendocrine secretory protein 55; Belongs to the NESP55 family. | 0.900 |
ADCY6 | NUDT2 | ENSBTAP00000007187 | ENSBTAP00000042493 | Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis. | 0.902 |
ADCY6 | PRKACA | ENSBTAP00000007187 | ENSBTAP00000063436 | Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] | 0.948 |
ADCY6 | PRKACB | ENSBTAP00000007187 | ENSBTAP00000046803 | Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, and differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these [...] | 0.954 |
ADCY6 | PRKCD | ENSBTAP00000007187 | ENSBTAP00000074537 | Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.903 |
ADCY6 | RAPGEF4 | ENSBTAP00000007187 | ENSBTAP00000053320 | Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Rap guanine nucleotide exchange factor 4. | 0.943 |
ADCY9 | ADCY3 | ENSBTAP00000059237 | ENSBTAP00000032877 | Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | 0.935 |