node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRD1 | BRPF1 | ENSBTAP00000055298 | ENSBTAP00000010224 | Bromodomain containing 1. | Bromodomain and PHD finger containing 1. | 0.697 |
BRD1 | BRPF3 | ENSBTAP00000055298 | ENSBTAP00000068627 | Bromodomain containing 1. | Bromodomain and PHD finger containing 3. | 0.853 |
BRD1 | HIST1H3C | ENSBTAP00000055298 | ENSBTAP00000059273 | Bromodomain containing 1. | Histone H3.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.653 |
BRD1 | ING4 | ENSBTAP00000055298 | ENSBTAP00000022686 | Bromodomain containing 1. | Inhibitor of growth protein 4; Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact [...] | 0.736 |
BRD1 | ING5 | ENSBTAP00000055298 | ENSBTAP00000012025 | Bromodomain containing 1. | Inhibitor of growth family member 5. | 0.813 |
BRD1 | KAT6B | ENSBTAP00000055298 | ENSBTAP00000060655 | Bromodomain containing 1. | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. | 0.843 |
BRD1 | KAT7 | ENSBTAP00000055298 | ENSBTAP00000024887 | Bromodomain containing 1. | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. | 0.953 |
BRD1 | MEAF6 | ENSBTAP00000055298 | ENSBTAP00000052635 | Bromodomain containing 1. | Chromatin modification-related protein MEAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vi [...] | 0.902 |
BRPF1 | BRD1 | ENSBTAP00000010224 | ENSBTAP00000055298 | Bromodomain and PHD finger containing 1. | Bromodomain containing 1. | 0.697 |
BRPF1 | BRPF3 | ENSBTAP00000010224 | ENSBTAP00000068627 | Bromodomain and PHD finger containing 1. | Bromodomain and PHD finger containing 3. | 0.727 |
BRPF1 | HIST1H3C | ENSBTAP00000010224 | ENSBTAP00000059273 | Bromodomain and PHD finger containing 1. | Histone H3.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.644 |
BRPF1 | ING4 | ENSBTAP00000010224 | ENSBTAP00000022686 | Bromodomain and PHD finger containing 1. | Inhibitor of growth protein 4; Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact [...] | 0.802 |
BRPF1 | ING5 | ENSBTAP00000010224 | ENSBTAP00000012025 | Bromodomain and PHD finger containing 1. | Inhibitor of growth family member 5. | 0.973 |
BRPF1 | KAT6B | ENSBTAP00000010224 | ENSBTAP00000060655 | Bromodomain and PHD finger containing 1. | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. | 0.928 |
BRPF1 | KAT7 | ENSBTAP00000010224 | ENSBTAP00000024887 | Bromodomain and PHD finger containing 1. | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. | 0.857 |
BRPF1 | MEAF6 | ENSBTAP00000010224 | ENSBTAP00000052635 | Bromodomain and PHD finger containing 1. | Chromatin modification-related protein MEAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vi [...] | 0.883 |
BRPF3 | BRD1 | ENSBTAP00000068627 | ENSBTAP00000055298 | Bromodomain and PHD finger containing 3. | Bromodomain containing 1. | 0.853 |
BRPF3 | BRPF1 | ENSBTAP00000068627 | ENSBTAP00000010224 | Bromodomain and PHD finger containing 3. | Bromodomain and PHD finger containing 1. | 0.727 |
BRPF3 | HIST1H3C | ENSBTAP00000068627 | ENSBTAP00000059273 | Bromodomain and PHD finger containing 3. | Histone H3.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.588 |
BRPF3 | ING4 | ENSBTAP00000068627 | ENSBTAP00000022686 | Bromodomain and PHD finger containing 3. | Inhibitor of growth protein 4; Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact [...] | 0.872 |