node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACBD4 | VAPA | ENSBTAP00000058658 | ENSBTAP00000064278 | Acyl-CoA-binding domain-containing protein 4; Binds medium- and long-chain acyl-CoA esters and may function as an intracellular carrier of acyl-CoA esters. | Vesicle-associated membrane protein-associated protein A; Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking. | 0.754 |
ACBD4 | VAPB | ENSBTAP00000058658 | ENSBTAP00000023164 | Acyl-CoA-binding domain-containing protein 4; Binds medium- and long-chain acyl-CoA esters and may function as an intracellular carrier of acyl-CoA esters. | Vesicle-associated membrane protein-associated protein B; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. | 0.841 |
ACBD5 | VAPA | ENSBTAP00000022964 | ENSBTAP00000064278 | Acyl-CoA-binding domain-containing protein 5; Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters (By similarity); Belongs to the ATG37 family. | Vesicle-associated membrane protein-associated protein A; Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking. | 0.795 |
ACBD5 | VAPB | ENSBTAP00000022964 | ENSBTAP00000023164 | Acyl-CoA-binding domain-containing protein 5; Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters (By similarity); Belongs to the ATG37 family. | Vesicle-associated membrane protein-associated protein B; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. | 0.849 |
CERT1 | OSBP | ENSBTAP00000000092 | ENSBTAP00000027095 | Ceramide transfer protein; Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. | Oxysterol-binding protein; Belongs to the OSBP family. | 0.640 |
CERT1 | PPM1L | ENSBTAP00000000092 | ENSBTAP00000050151 | Ceramide transfer protein; Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. | Protein phosphatase 1L; Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6. Belongs to the PP2C family. | 0.619 |
CERT1 | STARD3 | ENSBTAP00000000092 | ENSBTAP00000015578 | Ceramide transfer protein; Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. | StAR related lipid transfer domain containing 3. | 0.720 |
CERT1 | VAPA | ENSBTAP00000000092 | ENSBTAP00000064278 | Ceramide transfer protein; Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. | Vesicle-associated membrane protein-associated protein A; Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking. | 0.948 |
CERT1 | VAPB | ENSBTAP00000000092 | ENSBTAP00000023164 | Ceramide transfer protein; Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. | Vesicle-associated membrane protein-associated protein B; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. | 0.827 |
OSBP | CERT1 | ENSBTAP00000027095 | ENSBTAP00000000092 | Oxysterol-binding protein; Belongs to the OSBP family. | Ceramide transfer protein; Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. | 0.640 |
OSBP | PPM1L | ENSBTAP00000027095 | ENSBTAP00000050151 | Oxysterol-binding protein; Belongs to the OSBP family. | Protein phosphatase 1L; Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6. Belongs to the PP2C family. | 0.446 |
OSBP | STARD3 | ENSBTAP00000027095 | ENSBTAP00000015578 | Oxysterol-binding protein; Belongs to the OSBP family. | StAR related lipid transfer domain containing 3. | 0.645 |
OSBP | STARD3NL | ENSBTAP00000027095 | ENSBTAP00000050169 | Oxysterol-binding protein; Belongs to the OSBP family. | STARD3 N-terminal like. | 0.463 |
OSBP | VAPA | ENSBTAP00000027095 | ENSBTAP00000064278 | Oxysterol-binding protein; Belongs to the OSBP family. | Vesicle-associated membrane protein-associated protein A; Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking. | 0.992 |
OSBP | VAPB | ENSBTAP00000027095 | ENSBTAP00000023164 | Oxysterol-binding protein; Belongs to the OSBP family. | Vesicle-associated membrane protein-associated protein B; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. | 0.924 |
OSBP2 | VAPA | ENSBTAP00000073611 | ENSBTAP00000064278 | Oxysterol-binding protein; Belongs to the OSBP family. | Vesicle-associated membrane protein-associated protein A; Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking. | 0.749 |
OSBP2 | VAPB | ENSBTAP00000073611 | ENSBTAP00000023164 | Oxysterol-binding protein; Belongs to the OSBP family. | Vesicle-associated membrane protein-associated protein B; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. | 0.482 |
PPM1L | CERT1 | ENSBTAP00000050151 | ENSBTAP00000000092 | Protein phosphatase 1L; Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6. Belongs to the PP2C family. | Ceramide transfer protein; Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. | 0.619 |
PPM1L | OSBP | ENSBTAP00000050151 | ENSBTAP00000027095 | Protein phosphatase 1L; Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6. Belongs to the PP2C family. | Oxysterol-binding protein; Belongs to the OSBP family. | 0.446 |
PPM1L | VAPA | ENSBTAP00000050151 | ENSBTAP00000064278 | Protein phosphatase 1L; Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6. Belongs to the PP2C family. | Vesicle-associated membrane protein-associated protein A; Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking. | 0.814 |