node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ERCC1 | ERCC4 | ENSBTAP00000023078 | ENSBTAP00000043645 | DNA excision repair protein ERCC-1; Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity). | ERCC excision repair 4, endonuclease catalytic subunit. | 0.999 |
ERCC1 | FANCG | ENSBTAP00000023078 | ENSBTAP00000049770 | DNA excision repair protein ERCC-1; Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity). | FA complementation group G. | 0.924 |
ERCC1 | FANCL | ENSBTAP00000023078 | ENSBTAP00000007713 | DNA excision repair protein ERCC-1; Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity). | Fanconi anemia, complementation group L. | 0.932 |
ERCC1 | FANCM | ENSBTAP00000023078 | ENSBTAP00000073359 | DNA excision repair protein ERCC-1; Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity). | Uncharacterized protein. | 0.995 |
ERCC1 | MSH2 | ENSBTAP00000023078 | ENSBTAP00000003556 | DNA excision repair protein ERCC-1; Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity). | DNA mismatch repair protein Msh2; Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a t [...] | 0.954 |
ERCC1 | MUS81 | ENSBTAP00000023078 | ENSBTAP00000053117 | DNA excision repair protein ERCC-1; Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity). | MUS81 structure-specific endonuclease subunit. | 0.964 |
ERCC1 | RAD23B | ENSBTAP00000023078 | ENSBTAP00000002506 | DNA excision repair protein ERCC-1; Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity). | UV excision repair protein RAD23 homolog B; Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome (By similarity). The XPC complex is proposed to represent the first factor bound at the sites [...] | 0.938 |
ERCC1 | SLX1A | ENSBTAP00000023078 | ENSBTAP00000068428 | DNA excision repair protein ERCC-1; Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity). | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. | 0.948 |
ERCC1 | SLX4 | ENSBTAP00000023078 | ENSBTAP00000005923 | DNA excision repair protein ERCC-1; Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity). | SLX4 structure-specific endonuclease subunit. | 0.987 |
ERCC1 | XPA | ENSBTAP00000023078 | ENSBTAP00000012834 | DNA excision repair protein ERCC-1; Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity). | Xeroderma pigmentosum, complementation group A. | 0.997 |
ERCC4 | ERCC1 | ENSBTAP00000043645 | ENSBTAP00000023078 | ERCC excision repair 4, endonuclease catalytic subunit. | DNA excision repair protein ERCC-1; Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity). | 0.999 |
ERCC4 | FANCG | ENSBTAP00000043645 | ENSBTAP00000049770 | ERCC excision repair 4, endonuclease catalytic subunit. | FA complementation group G. | 0.942 |
ERCC4 | FANCL | ENSBTAP00000043645 | ENSBTAP00000007713 | ERCC excision repair 4, endonuclease catalytic subunit. | Fanconi anemia, complementation group L. | 0.933 |
ERCC4 | FANCM | ENSBTAP00000043645 | ENSBTAP00000073359 | ERCC excision repair 4, endonuclease catalytic subunit. | Uncharacterized protein. | 0.876 |
ERCC4 | MSH2 | ENSBTAP00000043645 | ENSBTAP00000003556 | ERCC excision repair 4, endonuclease catalytic subunit. | DNA mismatch repair protein Msh2; Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a t [...] | 0.874 |
ERCC4 | MUS81 | ENSBTAP00000043645 | ENSBTAP00000053117 | ERCC excision repair 4, endonuclease catalytic subunit. | MUS81 structure-specific endonuclease subunit. | 0.959 |
ERCC4 | RAD23B | ENSBTAP00000043645 | ENSBTAP00000002506 | ERCC excision repair 4, endonuclease catalytic subunit. | UV excision repair protein RAD23 homolog B; Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome (By similarity). The XPC complex is proposed to represent the first factor bound at the sites [...] | 0.840 |
ERCC4 | SLX1A | ENSBTAP00000043645 | ENSBTAP00000068428 | ERCC excision repair 4, endonuclease catalytic subunit. | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. | 0.924 |
ERCC4 | SLX4 | ENSBTAP00000043645 | ENSBTAP00000005923 | ERCC excision repair 4, endonuclease catalytic subunit. | SLX4 structure-specific endonuclease subunit. | 0.991 |
ERCC4 | XPA | ENSBTAP00000043645 | ENSBTAP00000012834 | ERCC excision repair 4, endonuclease catalytic subunit. | Xeroderma pigmentosum, complementation group A. | 0.987 |