node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BUB1B | CCNA2 | ENSBTAP00000009521 | ENSBTAP00000006503 | BUB1 mitotic checkpoint serine/threonine kinase B. | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | 0.985 |
BUB1B | CENPF | ENSBTAP00000009521 | ENSBTAP00000033816 | BUB1 mitotic checkpoint serine/threonine kinase B. | Centromere protein F. | 0.989 |
BUB1B | E2F8 | ENSBTAP00000009521 | ENSBTAP00000063720 | BUB1 mitotic checkpoint serine/threonine kinase B. | Transcription factor E2F8; Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta a [...] | 0.881 |
BUB1B | KIF11 | ENSBTAP00000009521 | ENSBTAP00000012347 | BUB1 mitotic checkpoint serine/threonine kinase B. | Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.990 |
BUB1B | KIF15 | ENSBTAP00000009521 | ENSBTAP00000053783 | BUB1 mitotic checkpoint serine/threonine kinase B. | Kinesin family member 15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.949 |
BUB1B | KIF2C | ENSBTAP00000009521 | ENSBTAP00000020322 | BUB1 mitotic checkpoint serine/threonine kinase B. | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.965 |
BUB1B | RRM2 | ENSBTAP00000009521 | ENSBTAP00000010802 | BUB1 mitotic checkpoint serine/threonine kinase B. | Ribonucleotide reductase regulatory subunit M2. | 0.943 |
BUB1B | TOP2A | ENSBTAP00000009521 | ENSBTAP00000053858 | BUB1 mitotic checkpoint serine/threonine kinase B. | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | 0.978 |
BUB1B | TTK | ENSBTAP00000009521 | ENSBTAP00000045797 | BUB1 mitotic checkpoint serine/threonine kinase B. | TTK protein kinase. | 0.982 |
CCNA2 | BUB1B | ENSBTAP00000006503 | ENSBTAP00000009521 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | BUB1 mitotic checkpoint serine/threonine kinase B. | 0.985 |
CCNA2 | CENPF | ENSBTAP00000006503 | ENSBTAP00000033816 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | Centromere protein F. | 0.939 |
CCNA2 | E2F7 | ENSBTAP00000006503 | ENSBTAP00000022518 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | Transcription factor E2F7; Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in po [...] | 0.572 |
CCNA2 | E2F8 | ENSBTAP00000006503 | ENSBTAP00000063720 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | Transcription factor E2F8; Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta a [...] | 0.888 |
CCNA2 | KIF11 | ENSBTAP00000006503 | ENSBTAP00000012347 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.971 |
CCNA2 | KIF15 | ENSBTAP00000006503 | ENSBTAP00000053783 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | Kinesin family member 15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.886 |
CCNA2 | KIF2C | ENSBTAP00000006503 | ENSBTAP00000020322 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.935 |
CCNA2 | RRM2 | ENSBTAP00000006503 | ENSBTAP00000010802 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | Ribonucleotide reductase regulatory subunit M2. | 0.955 |
CCNA2 | TOP2A | ENSBTAP00000006503 | ENSBTAP00000053858 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | 0.972 |
CCNA2 | TTK | ENSBTAP00000006503 | ENSBTAP00000045797 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | TTK protein kinase. | 0.942 |
CENPF | BUB1B | ENSBTAP00000033816 | ENSBTAP00000009521 | Centromere protein F. | BUB1 mitotic checkpoint serine/threonine kinase B. | 0.989 |