node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAM17 | ADAM9 | ENSBTAP00000001519 | ENSBTAP00000063154 | ADAM metallopeptidase domain 17. | ADAM metallopeptidase domain 9. | 0.522 |
ADAM17 | APP | ENSBTAP00000001519 | ENSBTAP00000060984 | ADAM metallopeptidase domain 17. | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.707 |
ADAM17 | BACE1 | ENSBTAP00000001519 | ENSBTAP00000039837 | ADAM metallopeptidase domain 17. | Beta-secretase 1; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (By similarity). Cleaves CHL1 (By similarity); Belongs to the peptidase A1 family. | 0.690 |
ADAM17 | MMP7 | ENSBTAP00000001519 | ENSBTAP00000006029 | ADAM metallopeptidase domain 17. | Matrix metallopeptidase 7. | 0.614 |
ADAM17 | NCSTN | ENSBTAP00000001519 | ENSBTAP00000068930 | ADAM metallopeptidase domain 17. | Nicastrin. | 0.755 |
ADAM17 | PSENEN | ENSBTAP00000001519 | ENSBTAP00000024745 | ADAM metallopeptidase domain 17. | Gamma-secretase subunit PEN-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity. | 0.647 |
ADAM9 | ADAM17 | ENSBTAP00000063154 | ENSBTAP00000001519 | ADAM metallopeptidase domain 9. | ADAM metallopeptidase domain 17. | 0.522 |
ADAM9 | APP | ENSBTAP00000063154 | ENSBTAP00000060984 | ADAM metallopeptidase domain 9. | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.591 |
ADAM9 | AVL9 | ENSBTAP00000063154 | ENSBTAP00000004049 | ADAM metallopeptidase domain 9. | AVL9 cell migration associated. | 0.518 |
ADAM9 | BACE1 | ENSBTAP00000063154 | ENSBTAP00000039837 | ADAM metallopeptidase domain 9. | Beta-secretase 1; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (By similarity). Cleaves CHL1 (By similarity); Belongs to the peptidase A1 family. | 0.569 |
ADAM9 | HTRA4 | ENSBTAP00000063154 | ENSBTAP00000004564 | ADAM metallopeptidase domain 9. | Serine protease HTR4; Serine protease; Belongs to the peptidase S1C family. | 0.477 |
ADAM9 | MMP7 | ENSBTAP00000063154 | ENSBTAP00000006029 | ADAM metallopeptidase domain 9. | Matrix metallopeptidase 7. | 0.484 |
ADAM9 | NCSTN | ENSBTAP00000063154 | ENSBTAP00000068930 | ADAM metallopeptidase domain 9. | Nicastrin. | 0.589 |
ADAM9 | PLEKHA2 | ENSBTAP00000063154 | ENSBTAP00000068621 | ADAM metallopeptidase domain 9. | Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). | 0.606 |
ADAM9 | PSENEN | ENSBTAP00000063154 | ENSBTAP00000024745 | ADAM metallopeptidase domain 9. | Gamma-secretase subunit PEN-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity. | 0.494 |
ADAM9 | TM2D2 | ENSBTAP00000063154 | ENSBTAP00000004567 | ADAM metallopeptidase domain 9. | TM2 domain-containing protein 2. | 0.499 |
APP | ADAM17 | ENSBTAP00000060984 | ENSBTAP00000001519 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | ADAM metallopeptidase domain 17. | 0.707 |
APP | ADAM9 | ENSBTAP00000060984 | ENSBTAP00000063154 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | ADAM metallopeptidase domain 9. | 0.591 |
APP | BACE1 | ENSBTAP00000060984 | ENSBTAP00000039837 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Beta-secretase 1; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (By similarity). Cleaves CHL1 (By similarity); Belongs to the peptidase A1 family. | 0.982 |
APP | NCSTN | ENSBTAP00000060984 | ENSBTAP00000068930 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Nicastrin. | 0.966 |