node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCNA1 | CCNA2 | ENSBTAP00000009579 | ENSBTAP00000006503 | Cyclin A1; Belongs to the cyclin family. | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | 0.956 |
CCNA1 | CCNE1 | ENSBTAP00000009579 | ENSBTAP00000006215 | Cyclin A1; Belongs to the cyclin family. | Cyclin E1; Belongs to the cyclin family. | 0.881 |
CCNA1 | CDK2 | ENSBTAP00000009579 | ENSBTAP00000005252 | Cyclin A1; Belongs to the cyclin family. | Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] | 0.999 |
CCNA1 | E2F1 | ENSBTAP00000009579 | ENSBTAP00000005182 | Cyclin A1; Belongs to the cyclin family. | E2F transcription factor 1. | 0.996 |
CCNA1 | E2F2 | ENSBTAP00000009579 | ENSBTAP00000023554 | Cyclin A1; Belongs to the cyclin family. | E2F transcription factor 2. | 0.967 |
CCNA1 | E2F3 | ENSBTAP00000009579 | ENSBTAP00000028030 | Cyclin A1; Belongs to the cyclin family. | E2F transcription factor 3. | 0.966 |
CCNA1 | RB1 | ENSBTAP00000009579 | ENSBTAP00000008728 | Cyclin A1; Belongs to the cyclin family. | RB transcriptional corepressor 1. | 0.971 |
CCNA1 | RBL1 | ENSBTAP00000009579 | ENSBTAP00000015333 | Cyclin A1; Belongs to the cyclin family. | RB transcriptional corepressor like 1. | 0.707 |
CCNA1 | RBL2 | ENSBTAP00000009579 | ENSBTAP00000062088 | Cyclin A1; Belongs to the cyclin family. | RB transcriptional corepressor like 2. | 0.743 |
CCNA1 | TFDP1 | ENSBTAP00000009579 | ENSBTAP00000067273 | Cyclin A1; Belongs to the cyclin family. | Transcription factor Dp-1; Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (By similarity). | 0.659 |
CCNA2 | CCNA1 | ENSBTAP00000006503 | ENSBTAP00000009579 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | Cyclin A1; Belongs to the cyclin family. | 0.956 |
CCNA2 | CCNE1 | ENSBTAP00000006503 | ENSBTAP00000006215 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | Cyclin E1; Belongs to the cyclin family. | 0.907 |
CCNA2 | CDK2 | ENSBTAP00000006503 | ENSBTAP00000005252 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] | 0.999 |
CCNA2 | E2F1 | ENSBTAP00000006503 | ENSBTAP00000005182 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | E2F transcription factor 1. | 0.998 |
CCNA2 | E2F2 | ENSBTAP00000006503 | ENSBTAP00000023554 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | E2F transcription factor 2. | 0.975 |
CCNA2 | E2F3 | ENSBTAP00000006503 | ENSBTAP00000028030 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | E2F transcription factor 3. | 0.966 |
CCNA2 | RB1 | ENSBTAP00000006503 | ENSBTAP00000008728 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | RB transcriptional corepressor 1. | 0.978 |
CCNA2 | RBL1 | ENSBTAP00000006503 | ENSBTAP00000015333 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | RB transcriptional corepressor like 1. | 0.866 |
CCNA2 | RBL2 | ENSBTAP00000006503 | ENSBTAP00000062088 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | RB transcriptional corepressor like 2. | 0.863 |
CCNA2 | TFDP1 | ENSBTAP00000006503 | ENSBTAP00000067273 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. | Transcription factor Dp-1; Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (By similarity). | 0.708 |