node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABRA | LRRC10 | ENSBTAP00000024417 | ENSBTAP00000025497 | Actin binding Rho activating protein. | Leucine-rich repeat-containing protein 10; May play important roles in cardiac development and/or cardiac function. | 0.584 |
ABRAXAS1 | LRRC10 | ENSBTAP00000018700 | ENSBTAP00000025497 | BRCA1-A complex subunit Abraxas 1; Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX; [...] | Leucine-rich repeat-containing protein 10; May play important roles in cardiac development and/or cardiac function. | 0.564 |
ADGRL1 | LRRC10 | ENSBTAP00000073270 | ENSBTAP00000025497 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity). | Leucine-rich repeat-containing protein 10; May play important roles in cardiac development and/or cardiac function. | 0.678 |
ADGRL2 | LRRC10 | ENSBTAP00000055886 | ENSBTAP00000025497 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. | Leucine-rich repeat-containing protein 10; May play important roles in cardiac development and/or cardiac function. | 0.678 |
ADGRL3 | LRRC10 | ENSBTAP00000049222 | ENSBTAP00000025497 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. | Leucine-rich repeat-containing protein 10; May play important roles in cardiac development and/or cardiac function. | 0.678 |
BEST3 | CCT2 | ENSBTAP00000003810 | ENSBTAP00000025496 | Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. | T-complex protein 1 subunit beta; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. | 0.426 |
BEST3 | LRRC10 | ENSBTAP00000003810 | ENSBTAP00000025497 | Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. | Leucine-rich repeat-containing protein 10; May play important roles in cardiac development and/or cardiac function. | 0.674 |
BEST3 | RAB3IP | ENSBTAP00000003810 | ENSBTAP00000022990 | Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. | RAB3A interacting protein (Rabin3). | 0.508 |
CCT2 | BEST3 | ENSBTAP00000025496 | ENSBTAP00000003810 | T-complex protein 1 subunit beta; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. | Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. | 0.426 |
CCT2 | FRS2 | ENSBTAP00000025496 | ENSBTAP00000025495 | T-complex protein 1 subunit beta; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. | Fibroblast growth factor receptor substrate 2. | 0.464 |
CCT2 | LRRC10 | ENSBTAP00000025496 | ENSBTAP00000025497 | T-complex protein 1 subunit beta; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. | Leucine-rich repeat-containing protein 10; May play important roles in cardiac development and/or cardiac function. | 0.591 |
CCT2 | YEATS4 | ENSBTAP00000025496 | ENSBTAP00000002913 | T-complex protein 1 subunit beta; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. | YEATS domain containing 4. | 0.479 |
FRS2 | CCT2 | ENSBTAP00000025495 | ENSBTAP00000025496 | Fibroblast growth factor receptor substrate 2. | T-complex protein 1 subunit beta; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. | 0.464 |
FRS2 | LRRC10 | ENSBTAP00000025495 | ENSBTAP00000025497 | Fibroblast growth factor receptor substrate 2. | Leucine-rich repeat-containing protein 10; May play important roles in cardiac development and/or cardiac function. | 0.569 |
FRS2 | YEATS4 | ENSBTAP00000025495 | ENSBTAP00000002913 | Fibroblast growth factor receptor substrate 2. | YEATS domain containing 4. | 0.646 |
LRRC10 | ABRA | ENSBTAP00000025497 | ENSBTAP00000024417 | Leucine-rich repeat-containing protein 10; May play important roles in cardiac development and/or cardiac function. | Actin binding Rho activating protein. | 0.584 |
LRRC10 | ABRAXAS1 | ENSBTAP00000025497 | ENSBTAP00000018700 | Leucine-rich repeat-containing protein 10; May play important roles in cardiac development and/or cardiac function. | BRCA1-A complex subunit Abraxas 1; Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX; [...] | 0.564 |
LRRC10 | ADGRL1 | ENSBTAP00000025497 | ENSBTAP00000073270 | Leucine-rich repeat-containing protein 10; May play important roles in cardiac development and/or cardiac function. | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity). | 0.678 |
LRRC10 | ADGRL2 | ENSBTAP00000025497 | ENSBTAP00000055886 | Leucine-rich repeat-containing protein 10; May play important roles in cardiac development and/or cardiac function. | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. | 0.678 |
LRRC10 | ADGRL3 | ENSBTAP00000025497 | ENSBTAP00000049222 | Leucine-rich repeat-containing protein 10; May play important roles in cardiac development and/or cardiac function. | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. | 0.678 |