node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CALHM1 | SCN2A | ENSBTAP00000009263 | ENSBTAP00000053208 | Calcium homeostasis modulator 1. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.903 |
CALHM1 | SCN3A | ENSBTAP00000009263 | ENSBTAP00000025829 | Calcium homeostasis modulator 1. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.903 |
CALHM1 | SCN9A | ENSBTAP00000009263 | ENSBTAP00000003146 | Calcium homeostasis modulator 1. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.903 |
ENSBTAP00000066836 | SCN1B | ENSBTAP00000066836 | ENSBTAP00000004980 | Uncharacterized protein. | Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. | 0.814 |
ENSBTAP00000066836 | SCN2A | ENSBTAP00000066836 | ENSBTAP00000053208 | Uncharacterized protein. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.540 |
ENSBTAP00000066836 | SCN2B | ENSBTAP00000066836 | ENSBTAP00000073533 | Uncharacterized protein. | Uncharacterized protein. | 0.746 |
ENSBTAP00000066836 | SCN3A | ENSBTAP00000066836 | ENSBTAP00000025829 | Uncharacterized protein. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.911 |
ENSBTAP00000066836 | SCN3B | ENSBTAP00000066836 | ENSBTAP00000066197 | Uncharacterized protein. | Sodium channel subunit beta-3; Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity). | 0.691 |
ENSBTAP00000066836 | SCN4B | ENSBTAP00000066836 | ENSBTAP00000017826 | Uncharacterized protein. | Sodium channel subunit beta-4; Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom (By similarity). | 0.677 |
ENSBTAP00000066836 | UNC79 | ENSBTAP00000066836 | ENSBTAP00000055325 | Uncharacterized protein. | Unc-79 homolog, NALCN channel complex subunit. | 0.675 |
KCNQ2 | SCN1B | ENSBTAP00000067696 | ENSBTAP00000004980 | Potassium voltage-gated channel subfamily Q member 2; Belongs to the potassium channel family. | Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. | 0.452 |
KCNQ2 | SCN2A | ENSBTAP00000067696 | ENSBTAP00000053208 | Potassium voltage-gated channel subfamily Q member 2; Belongs to the potassium channel family. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.563 |
KCNQ2 | SCN2B | ENSBTAP00000067696 | ENSBTAP00000073533 | Potassium voltage-gated channel subfamily Q member 2; Belongs to the potassium channel family. | Uncharacterized protein. | 0.422 |
KCNQ2 | SCN3A | ENSBTAP00000067696 | ENSBTAP00000025829 | Potassium voltage-gated channel subfamily Q member 2; Belongs to the potassium channel family. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.563 |
KCNQ2 | SCN9A | ENSBTAP00000067696 | ENSBTAP00000003146 | Potassium voltage-gated channel subfamily Q member 2; Belongs to the potassium channel family. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.537 |
SCN1B | ENSBTAP00000066836 | ENSBTAP00000004980 | ENSBTAP00000066836 | Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. | Uncharacterized protein. | 0.814 |
SCN1B | KCNQ2 | ENSBTAP00000004980 | ENSBTAP00000067696 | Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. | Potassium voltage-gated channel subfamily Q member 2; Belongs to the potassium channel family. | 0.452 |
SCN1B | SCN2A | ENSBTAP00000004980 | ENSBTAP00000053208 | Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.939 |
SCN1B | SCN2B | ENSBTAP00000004980 | ENSBTAP00000073533 | Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. | Uncharacterized protein. | 0.984 |
SCN1B | SCN3A | ENSBTAP00000004980 | ENSBTAP00000025829 | Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.934 |