STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TSPAN8Tetraspanin-8. (238 aa)    
Predicted Functional Partners:
ITGA4
Integrin subunit alpha 4; Belongs to the integrin alpha chain family.
   
 
 0.805
ABHD15
Abhydrolase domain containing 15.
      
 0.605
EPCAM
Epithelial cell adhesion molecule; May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E (By similarity). Belongs to the EPCAM family.
      
 0.588
LGALS2
Galectin.
   
 
 0.574
TM4SF4
Transmembrane 4 L six family member 4.
      
 0.560
ATXN3
ATXN3 protein.
      
 0.508
PTCH1
SSD domain-containing protein.
    
 
 0.503
CDC123
Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle.
      
 0.501
SLC30A8
Solute carrier family 30 member 8.
    
 
 0.501
ANKS4B
Ankyrin repeat and sterile alpha motif domain containing 4B.
   
  
 0.500
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.