STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPACA1Sperm acrosome membrane-associated protein 1; Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis. Important for male fertility. (280 aa)    
Predicted Functional Partners:
IZUMO1
Izumo sperm-egg fusion 1.
      
 0.904
SSMEM1
Serine rich single-pass membrane protein 1.
      
 0.893
DPY19L2
Dpy-19 like 2.
      
 0.853
SPATA16
Spermatogenesis associated 16.
      
 0.795
SPATA46
Spermatogenesis-associated protein 46; Plays a role in spermiogenesis and fertilization.
      
 0.774
TSSK4
Testis specific serine kinase 4; Belongs to the protein kinase superfamily.
    
 
 0.762
TMEM190
Transmembrane protein 190.
      
 0.741
VPS54
VPS54 subunit of GARP complex.
      
 0.738
SPACA3
Sperm acrosome membrane-associated protein 3; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N- acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro (By similarity).
      
 0.734
GOPC
Golgi associated PDZ and coiled-coil motif containing.
      
 0.732
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.