node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADGRL1 | PIDD1 | ENSBTAP00000073270 | ENSBTAP00000026157 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity). | P53-induced death domain protein 1. | 0.726 |
ADGRL1 | UNC5CL | ENSBTAP00000073270 | ENSBTAP00000003791 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity). | Unc-5 family C-terminal like. | 0.973 |
ADGRL2 | PIDD1 | ENSBTAP00000055886 | ENSBTAP00000026157 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. | P53-induced death domain protein 1. | 0.726 |
ADGRL2 | UNC5CL | ENSBTAP00000055886 | ENSBTAP00000003791 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. | Unc-5 family C-terminal like. | 0.973 |
ADGRL3 | PIDD1 | ENSBTAP00000049222 | ENSBTAP00000026157 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. | P53-induced death domain protein 1. | 0.726 |
ADGRL3 | UNC5CL | ENSBTAP00000049222 | ENSBTAP00000003791 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. | Unc-5 family C-terminal like. | 0.973 |
ATM | CASP2 | ENSBTAP00000039884 | ENSBTAP00000068904 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Caspase 2; Belongs to the peptidase C14A family. | 0.454 |
ATM | PIDD1 | ENSBTAP00000039884 | ENSBTAP00000026157 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | P53-induced death domain protein 1. | 0.800 |
BID | CASP2 | ENSBTAP00000040367 | ENSBTAP00000068904 | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | Caspase 2; Belongs to the peptidase C14A family. | 0.946 |
BID | PIDD1 | ENSBTAP00000040367 | ENSBTAP00000026157 | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | P53-induced death domain protein 1. | 0.914 |
CASP2 | ATM | ENSBTAP00000068904 | ENSBTAP00000039884 | Caspase 2; Belongs to the peptidase C14A family. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.454 |
CASP2 | BID | ENSBTAP00000068904 | ENSBTAP00000040367 | Caspase 2; Belongs to the peptidase C14A family. | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | 0.946 |
CASP2 | CRADD | ENSBTAP00000068904 | ENSBTAP00000067732 | Caspase 2; Belongs to the peptidase C14A family. | CASP2 and RIPK1 domain containing adaptor with death domain. | 0.965 |
CASP2 | PIDD1 | ENSBTAP00000068904 | ENSBTAP00000026157 | Caspase 2; Belongs to the peptidase C14A family. | P53-induced death domain protein 1. | 0.943 |
CRADD | CASP2 | ENSBTAP00000067732 | ENSBTAP00000068904 | CASP2 and RIPK1 domain containing adaptor with death domain. | Caspase 2; Belongs to the peptidase C14A family. | 0.965 |
CRADD | PIDD1 | ENSBTAP00000067732 | ENSBTAP00000026157 | CASP2 and RIPK1 domain containing adaptor with death domain. | P53-induced death domain protein 1. | 0.993 |
IKZF5 | PIDD1 | ENSBTAP00000064053 | ENSBTAP00000026157 | Zinc finger protein Pegasus; DNA-binding protein that binds to the 5'GNNTGTNG-3' core sequence. Transcriptional repressor (By similarity); Belongs to the Ikaros C2H2-type zinc-finger protein family. | P53-induced death domain protein 1. | 0.639 |
OLFM2 | PIDD1 | ENSBTAP00000009935 | ENSBTAP00000026157 | Olfactomedin 2. | P53-induced death domain protein 1. | 0.647 |
PIDD1 | ADGRL1 | ENSBTAP00000026157 | ENSBTAP00000073270 | P53-induced death domain protein 1. | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity). | 0.726 |
PIDD1 | ADGRL2 | ENSBTAP00000026157 | ENSBTAP00000055886 | P53-induced death domain protein 1. | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. | 0.726 |