node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACCS | EXT2 | ENSBTAP00000041743 | ENSBTAP00000026177 | 1-aminocyclopropane-1-carboxylate synthase-like protein 1; Does not catalyze the synthesis of 1-aminocyclopropane-1- carboxylate but is capable of catalyzing the deamination of L- vinylglycine. | Exostosin-2; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan. | 0.848 |
ACCSL | EXT2 | ENSBTAP00000015998 | ENSBTAP00000026177 | 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) like. | Exostosin-2; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan. | 0.802 |
B4GALT7 | EXT1 | ENSBTAP00000035533 | ENSBTAP00000008154 | Beta-1,4-galactosyltransferase 7. | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). | 0.739 |
B4GALT7 | EXT2 | ENSBTAP00000035533 | ENSBTAP00000026177 | Beta-1,4-galactosyltransferase 7. | Exostosin-2; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan. | 0.732 |
B4GALT7 | EXTL1 | ENSBTAP00000035533 | ENSBTAP00000071673 | Beta-1,4-galactosyltransferase 7. | Exostosin like glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. | 0.633 |
B4GALT7 | HS2ST1 | ENSBTAP00000035533 | ENSBTAP00000064686 | Beta-1,4-galactosyltransferase 7. | Uncharacterized protein. | 0.803 |
B4GALT7 | NDST1 | ENSBTAP00000035533 | ENSBTAP00000016824 | Beta-1,4-galactosyltransferase 7. | N-deacetylase and N-sulfotransferase 1. | 0.729 |
B4GALT7 | SLC35B2 | ENSBTAP00000035533 | ENSBTAP00000010620 | Beta-1,4-galactosyltransferase 7. | Solute carrier family 35, member B2. | 0.825 |
B4GALT7 | XYLT2 | ENSBTAP00000035533 | ENSBTAP00000063295 | Beta-1,4-galactosyltransferase 7. | Xylosyltransferase 2; Catalyzes the first step in the biosynthesis of chondroitin sulfate, heparan sulfate and dermatan sulfate proteoglycans, such as DCN (By similarity). Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein (By similarity). Belongs to the glycosyltransferase 14 family. XylT subfamily. | 0.810 |
EXT1 | B4GALT7 | ENSBTAP00000008154 | ENSBTAP00000035533 | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). | Beta-1,4-galactosyltransferase 7. | 0.739 |
EXT1 | EXT2 | ENSBTAP00000008154 | ENSBTAP00000026177 | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). | Exostosin-2; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan. | 0.998 |
EXT1 | HS2ST1 | ENSBTAP00000008154 | ENSBTAP00000064686 | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). | Uncharacterized protein. | 0.832 |
EXT1 | NDST1 | ENSBTAP00000008154 | ENSBTAP00000016824 | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). | N-deacetylase and N-sulfotransferase 1. | 0.859 |
EXT1 | NDST2 | ENSBTAP00000008154 | ENSBTAP00000016827 | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). | 0.820 |
EXT1 | SLC35B2 | ENSBTAP00000008154 | ENSBTAP00000010620 | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). | Solute carrier family 35, member B2. | 0.730 |
EXT1 | XYLT2 | ENSBTAP00000008154 | ENSBTAP00000063295 | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). | Xylosyltransferase 2; Catalyzes the first step in the biosynthesis of chondroitin sulfate, heparan sulfate and dermatan sulfate proteoglycans, such as DCN (By similarity). Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein (By similarity). Belongs to the glycosyltransferase 14 family. XylT subfamily. | 0.720 |
EXT2 | ACCS | ENSBTAP00000026177 | ENSBTAP00000041743 | Exostosin-2; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan. | 1-aminocyclopropane-1-carboxylate synthase-like protein 1; Does not catalyze the synthesis of 1-aminocyclopropane-1- carboxylate but is capable of catalyzing the deamination of L- vinylglycine. | 0.848 |
EXT2 | ACCSL | ENSBTAP00000026177 | ENSBTAP00000015998 | Exostosin-2; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan. | 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) like. | 0.802 |
EXT2 | B4GALT7 | ENSBTAP00000026177 | ENSBTAP00000035533 | Exostosin-2; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan. | Beta-1,4-galactosyltransferase 7. | 0.732 |
EXT2 | EXT1 | ENSBTAP00000026177 | ENSBTAP00000008154 | Exostosin-2; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan. | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). | 0.998 |