node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAP2 | DDHD1 | ENSBTAP00000004381 | ENSBTAP00000070741 | Uncharacterized protein. | Phospholipase DDHD1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. Required for the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (By similarity). | 0.554 |
C18H19orf12 | DDHD1 | ENSBTAP00000067866 | ENSBTAP00000070741 | Protein C19orf12 homolog. | Phospholipase DDHD1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. Required for the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (By similarity). | 0.748 |
C18H19orf12 | DDHD2 | ENSBTAP00000067866 | ENSBTAP00000017473 | Protein C19orf12 homolog. | DDHD domain containing 2. | 0.660 |
C18H19orf12 | FA2H | ENSBTAP00000067866 | ENSBTAP00000016212 | Protein C19orf12 homolog. | Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] | 0.729 |
C18H19orf12 | GBA2 | ENSBTAP00000067866 | ENSBTAP00000015194 | Protein C19orf12 homolog. | Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. | 0.648 |
DDHD1 | ACAP2 | ENSBTAP00000070741 | ENSBTAP00000004381 | Phospholipase DDHD1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. Required for the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (By similarity). | Uncharacterized protein. | 0.554 |
DDHD1 | C18H19orf12 | ENSBTAP00000070741 | ENSBTAP00000067866 | Phospholipase DDHD1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. Required for the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (By similarity). | Protein C19orf12 homolog. | 0.748 |
DDHD1 | DDHD2 | ENSBTAP00000070741 | ENSBTAP00000017473 | Phospholipase DDHD1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. Required for the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (By similarity). | DDHD domain containing 2. | 0.935 |
DDHD1 | ERI2 | ENSBTAP00000070741 | ENSBTAP00000074312 | Phospholipase DDHD1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. Required for the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (By similarity). | Exonuclease domain-containing protein. | 0.570 |
DDHD1 | FA2H | ENSBTAP00000070741 | ENSBTAP00000016212 | Phospholipase DDHD1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. Required for the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (By similarity). | Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] | 0.542 |
DDHD1 | GBA2 | ENSBTAP00000070741 | ENSBTAP00000015194 | Phospholipase DDHD1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. Required for the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (By similarity). | Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. | 0.636 |
DDHD1 | PLD6 | ENSBTAP00000070741 | ENSBTAP00000010531 | Phospholipase DDHD1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. Required for the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (By similarity). | Mitochondrial cardiolipin hydrolase; Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements. piRNA- mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as [...] | 0.605 |
DDHD1 | PNLIPRP2 | ENSBTAP00000070741 | ENSBTAP00000015106 | Phospholipase DDHD1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. Required for the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (By similarity). | Pancreatic lipase-related protein 2; Lipase with broad substrate specificity. Can hydrolyze both phospholipids and galactolipids. Acts preferentially on monoglycerides, phospholipids and galactolipids. Contributes to milk fat hydrolysis (By similarity). | 0.565 |
DDHD1 | PNPLA6 | ENSBTAP00000070741 | ENSBTAP00000062870 | Phospholipase DDHD1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. Required for the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (By similarity). | Patatin like phospholipase domain containing 6. | 0.580 |
DDHD1 | REEP1 | ENSBTAP00000070741 | ENSBTAP00000064769 | Phospholipase DDHD1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. Required for the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (By similarity). | Receptor expression-enhancing protein. | 0.604 |
DDHD2 | C18H19orf12 | ENSBTAP00000017473 | ENSBTAP00000067866 | DDHD domain containing 2. | Protein C19orf12 homolog. | 0.660 |
DDHD2 | DDHD1 | ENSBTAP00000017473 | ENSBTAP00000070741 | DDHD domain containing 2. | Phospholipase DDHD1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. Required for the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (By similarity). | 0.935 |
DDHD2 | FA2H | ENSBTAP00000017473 | ENSBTAP00000016212 | DDHD domain containing 2. | Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] | 0.536 |
DDHD2 | GBA2 | ENSBTAP00000017473 | ENSBTAP00000015194 | DDHD domain containing 2. | Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. | 0.622 |
DDHD2 | PNPLA6 | ENSBTAP00000017473 | ENSBTAP00000062870 | DDHD domain containing 2. | Patatin like phospholipase domain containing 6. | 0.815 |