node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARMC8 | DDX50 | ENSBTAP00000065769 | ENSBTAP00000022002 | Armadillo repeat-containing protein 8; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. | DExD-box helicase 50. | 0.930 |
ARMC8 | GID4 | ENSBTAP00000065769 | ENSBTAP00000011595 | Armadillo repeat-containing protein 8; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. | GID complex subunit 4 homolog. | 0.969 |
ARMC8 | GID8 | ENSBTAP00000065769 | ENSBTAP00000002387 | Armadillo repeat-containing protein 8; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. | Glucose-induced degradation protein 8 homolog; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation; Belongs to the GID8 family. | 0.992 |
ARMC8 | MAEA | ENSBTAP00000065769 | ENSBTAP00000016693 | Armadillo repeat-containing protein 8; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. | E3 ubiquitin-protein transferase MAEA; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin- protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity). Plays a role in erythroblast enucleat [...] | 0.971 |
ARMC8 | MKLN1 | ENSBTAP00000065769 | ENSBTAP00000013788 | Armadillo repeat-containing protein 8; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. | MKLN1 protein. | 0.911 |
ARMC8 | RANBP10 | ENSBTAP00000065769 | ENSBTAP00000073565 | Armadillo repeat-containing protein 8; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. | Ran-binding protein 10; May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for [...] | 0.984 |
ARMC8 | RMND5A | ENSBTAP00000065769 | ENSBTAP00000028174 | Armadillo repeat-containing protein 8; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. | Required for meiotic nuclear division 5 homolog A. | 0.951 |
ARMC8 | RMND5B | ENSBTAP00000065769 | ENSBTAP00000008362 | Armadillo repeat-containing protein 8; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. | Required for meiotic nuclear division 5 homolog B (S. cerevisiae). | 0.983 |
ARMC8 | WDR26 | ENSBTAP00000065769 | ENSBTAP00000034100 | Armadillo repeat-containing protein 8; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. | WD repeat domain 26. | 0.985 |
ARMC8 | ZMYND19 | ENSBTAP00000065769 | ENSBTAP00000016109 | Armadillo repeat-containing protein 8; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. | Zinc finger MYND-type containing 19. | 0.947 |
DDX50 | ARMC8 | ENSBTAP00000022002 | ENSBTAP00000065769 | DExD-box helicase 50. | Armadillo repeat-containing protein 8; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. | 0.930 |
DDX50 | MAEA | ENSBTAP00000022002 | ENSBTAP00000016693 | DExD-box helicase 50. | E3 ubiquitin-protein transferase MAEA; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin- protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity). Plays a role in erythroblast enucleat [...] | 0.473 |
DDX50 | MKLN1 | ENSBTAP00000022002 | ENSBTAP00000013788 | DExD-box helicase 50. | MKLN1 protein. | 0.409 |
DDX50 | RANBP10 | ENSBTAP00000022002 | ENSBTAP00000073565 | DExD-box helicase 50. | Ran-binding protein 10; May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for [...] | 0.595 |
DDX50 | RMND5B | ENSBTAP00000022002 | ENSBTAP00000008362 | DExD-box helicase 50. | Required for meiotic nuclear division 5 homolog B (S. cerevisiae). | 0.576 |
DDX50 | ZMYND19 | ENSBTAP00000022002 | ENSBTAP00000016109 | DExD-box helicase 50. | Zinc finger MYND-type containing 19. | 0.599 |
GID4 | ARMC8 | ENSBTAP00000011595 | ENSBTAP00000065769 | GID complex subunit 4 homolog. | Armadillo repeat-containing protein 8; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. | 0.969 |
GID4 | GID8 | ENSBTAP00000011595 | ENSBTAP00000002387 | GID complex subunit 4 homolog. | Glucose-induced degradation protein 8 homolog; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation; Belongs to the GID8 family. | 0.987 |
GID4 | MAEA | ENSBTAP00000011595 | ENSBTAP00000016693 | GID complex subunit 4 homolog. | E3 ubiquitin-protein transferase MAEA; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin- protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity). Plays a role in erythroblast enucleat [...] | 0.773 |
GID4 | MKLN1 | ENSBTAP00000011595 | ENSBTAP00000013788 | GID complex subunit 4 homolog. | MKLN1 protein. | 0.769 |