node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABHD10 | ABHD12B | ENSBTAP00000006038 | ENSBTAP00000053557 | Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Belongs to the AB hydrolase superfamily. | Abhydrolase domain containing 12B. | 0.700 |
ABHD10 | ABHD2 | ENSBTAP00000006038 | ENSBTAP00000026579 | Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Belongs to the AB hydrolase superfamily. | Monoacylglycerol lipase ABHD2; Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1- arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2A [...] | 0.595 |
ABHD10 | ABHD4 | ENSBTAP00000006038 | ENSBTAP00000022154 | Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Belongs to the AB hydrolase superfamily. | (Lyso)-N-acylphosphatidylethanolamine lipase; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N- acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatid [...] | 0.589 |
ABHD10 | ABHD8 | ENSBTAP00000006038 | ENSBTAP00000036358 | Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Belongs to the AB hydrolase superfamily. | Protein ABHD8; Belongs to the AB hydrolase superfamily. | 0.535 |
ABHD10 | SIAE | ENSBTAP00000006038 | ENSBTAP00000030276 | Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Belongs to the AB hydrolase superfamily. | Sialic acid acetylesterase. | 0.480 |
ABHD12B | ABHD10 | ENSBTAP00000053557 | ENSBTAP00000006038 | Abhydrolase domain containing 12B. | Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Belongs to the AB hydrolase superfamily. | 0.700 |
ABHD12B | ABHD16B | ENSBTAP00000053557 | ENSBTAP00000055253 | Abhydrolase domain containing 12B. | Chromosome 20 open reading frame 135 ortholog. | 0.422 |
ABHD12B | ABHD2 | ENSBTAP00000053557 | ENSBTAP00000026579 | Abhydrolase domain containing 12B. | Monoacylglycerol lipase ABHD2; Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1- arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2A [...] | 0.573 |
ABHD12B | ABHD4 | ENSBTAP00000053557 | ENSBTAP00000022154 | Abhydrolase domain containing 12B. | (Lyso)-N-acylphosphatidylethanolamine lipase; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N- acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatid [...] | 0.699 |
ABHD12B | ABHD8 | ENSBTAP00000053557 | ENSBTAP00000036358 | Abhydrolase domain containing 12B. | Protein ABHD8; Belongs to the AB hydrolase superfamily. | 0.648 |
ABHD16B | ABHD12B | ENSBTAP00000055253 | ENSBTAP00000053557 | Chromosome 20 open reading frame 135 ortholog. | Abhydrolase domain containing 12B. | 0.422 |
ABHD16B | ABHD2 | ENSBTAP00000055253 | ENSBTAP00000026579 | Chromosome 20 open reading frame 135 ortholog. | Monoacylglycerol lipase ABHD2; Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1- arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2A [...] | 0.628 |
ABHD2 | ABHD10 | ENSBTAP00000026579 | ENSBTAP00000006038 | Monoacylglycerol lipase ABHD2; Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1- arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2A [...] | Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Belongs to the AB hydrolase superfamily. | 0.595 |
ABHD2 | ABHD12B | ENSBTAP00000026579 | ENSBTAP00000053557 | Monoacylglycerol lipase ABHD2; Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1- arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2A [...] | Abhydrolase domain containing 12B. | 0.573 |
ABHD2 | ABHD16B | ENSBTAP00000026579 | ENSBTAP00000055253 | Monoacylglycerol lipase ABHD2; Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1- arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2A [...] | Chromosome 20 open reading frame 135 ortholog. | 0.628 |
ABHD2 | ABHD4 | ENSBTAP00000026579 | ENSBTAP00000022154 | Monoacylglycerol lipase ABHD2; Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1- arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2A [...] | (Lyso)-N-acylphosphatidylethanolamine lipase; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N- acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatid [...] | 0.660 |
ABHD2 | ABHD8 | ENSBTAP00000026579 | ENSBTAP00000036358 | Monoacylglycerol lipase ABHD2; Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1- arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2A [...] | Protein ABHD8; Belongs to the AB hydrolase superfamily. | 0.572 |
ABHD2 | BREH1 | ENSBTAP00000026579 | ENSBTAP00000032392 | Monoacylglycerol lipase ABHD2; Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1- arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2A [...] | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | 0.556 |
ABHD2 | CATSPER1 | ENSBTAP00000026579 | ENSBTAP00000019586 | Monoacylglycerol lipase ABHD2; Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1- arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2A [...] | Cation channel sperm associated 1. | 0.656 |
ABHD2 | ELF2 | ENSBTAP00000026579 | ENSBTAP00000045405 | Monoacylglycerol lipase ABHD2; Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1- arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2A [...] | E74 like ETS transcription factor 2. | 0.592 |