node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AHSA1 | CLPB | ENSBTAP00000035425 | ENSBTAP00000001687 | AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (Yeast). | Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process. | 0.526 |
AHSA1 | ENSBTAP00000074523 | ENSBTAP00000035425 | ENSBTAP00000074523 | AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (Yeast). | TPR_REGION domain-containing protein. | 0.747 |
AHSA1 | HSPD1-2 | ENSBTAP00000035425 | ENSBTAP00000059077 | AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (Yeast). | 60 kDa heat shock protein, mitochondrial; Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per rin [...] | 0.594 |
AHSA1 | PPP5C | ENSBTAP00000035425 | ENSBTAP00000010538 | AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (Yeast). | Serine/threonine-protein phosphatase. | 0.523 |
AHSA1 | STIP1 | ENSBTAP00000035425 | ENSBTAP00000059641 | AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (Yeast). | Stress-induced-phosphoprotein 1. | 0.790 |
AHSA1 | STIP1-2 | ENSBTAP00000035425 | ENSBTAP00000059610 | AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (Yeast). | Stress-induced-phosphoprotein 1; Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90. | 0.904 |
AHSA1 | TRAP1 | ENSBTAP00000035425 | ENSBTAP00000073291 | AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (Yeast). | Heat shock protein 75 kDa, mitochondrial; Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. | 0.719 |
AHSA2 | CLPB | ENSBTAP00000050140 | ENSBTAP00000001687 | Activator of 90 kDa heat shock protein ATPase homolog 2; Co-chaperone that stimulates HSP90 ATPase activity. | Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process. | 0.526 |
AHSA2 | ENSBTAP00000074523 | ENSBTAP00000050140 | ENSBTAP00000074523 | Activator of 90 kDa heat shock protein ATPase homolog 2; Co-chaperone that stimulates HSP90 ATPase activity. | TPR_REGION domain-containing protein. | 0.747 |
AHSA2 | HSPD1-2 | ENSBTAP00000050140 | ENSBTAP00000059077 | Activator of 90 kDa heat shock protein ATPase homolog 2; Co-chaperone that stimulates HSP90 ATPase activity. | 60 kDa heat shock protein, mitochondrial; Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per rin [...] | 0.540 |
AHSA2 | STIP1 | ENSBTAP00000050140 | ENSBTAP00000059641 | Activator of 90 kDa heat shock protein ATPase homolog 2; Co-chaperone that stimulates HSP90 ATPase activity. | Stress-induced-phosphoprotein 1. | 0.809 |
AHSA2 | STIP1-2 | ENSBTAP00000050140 | ENSBTAP00000059610 | Activator of 90 kDa heat shock protein ATPase homolog 2; Co-chaperone that stimulates HSP90 ATPase activity. | Stress-induced-phosphoprotein 1; Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90. | 0.802 |
AHSA2 | TRAP1 | ENSBTAP00000050140 | ENSBTAP00000073291 | Activator of 90 kDa heat shock protein ATPase homolog 2; Co-chaperone that stimulates HSP90 ATPase activity. | Heat shock protein 75 kDa, mitochondrial; Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. | 0.700 |
CLPB | AHSA1 | ENSBTAP00000001687 | ENSBTAP00000035425 | Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process. | AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (Yeast). | 0.526 |
CLPB | AHSA2 | ENSBTAP00000001687 | ENSBTAP00000050140 | Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process. | Activator of 90 kDa heat shock protein ATPase homolog 2; Co-chaperone that stimulates HSP90 ATPase activity. | 0.526 |
CLPB | ENSBTAP00000074523 | ENSBTAP00000001687 | ENSBTAP00000074523 | Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process. | TPR_REGION domain-containing protein. | 0.580 |
CLPB | HSPD1-2 | ENSBTAP00000001687 | ENSBTAP00000059077 | Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process. | 60 kDa heat shock protein, mitochondrial; Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per rin [...] | 0.731 |
CLPB | STIP1 | ENSBTAP00000001687 | ENSBTAP00000059641 | Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process. | Stress-induced-phosphoprotein 1. | 0.580 |
CLPB | STIP1-2 | ENSBTAP00000001687 | ENSBTAP00000059610 | Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process. | Stress-induced-phosphoprotein 1; Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90. | 0.683 |
CLPB | TRAP1 | ENSBTAP00000001687 | ENSBTAP00000073291 | Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process. | Heat shock protein 75 kDa, mitochondrial; Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. | 0.676 |