node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGEF12 | ARHGEF6 | ENSBTAP00000073305 | ENSBTAP00000023731 | Rho guanine nucleotide exchange factor 12. | Rac/Cdc42 guanine nucleotide exchange factor 6. | 0.906 |
ARHGEF12 | ARHGEF7 | ENSBTAP00000073305 | ENSBTAP00000027619 | Rho guanine nucleotide exchange factor 12. | Rho guanine nucleotide exchange factor 7. | 0.936 |
ARHGEF12 | CDC42 | ENSBTAP00000073305 | ENSBTAP00000059852 | Rho guanine nucleotide exchange factor 12. | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | 0.697 |
ARHGEF12 | PAK6 | ENSBTAP00000073305 | ENSBTAP00000025396 | Rho guanine nucleotide exchange factor 12. | Non-specific serine/threonine protein kinase. | 0.582 |
ARHGEF6 | ARHGEF12 | ENSBTAP00000023731 | ENSBTAP00000073305 | Rac/Cdc42 guanine nucleotide exchange factor 6. | Rho guanine nucleotide exchange factor 12. | 0.906 |
ARHGEF6 | ARHGEF7 | ENSBTAP00000023731 | ENSBTAP00000027619 | Rac/Cdc42 guanine nucleotide exchange factor 6. | Rho guanine nucleotide exchange factor 7. | 0.942 |
ARHGEF6 | CDC42 | ENSBTAP00000023731 | ENSBTAP00000059852 | Rac/Cdc42 guanine nucleotide exchange factor 6. | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | 0.779 |
ARHGEF6 | GIT1 | ENSBTAP00000023731 | ENSBTAP00000069881 | Rac/Cdc42 guanine nucleotide exchange factor 6. | GIT ArfGAP 1. | 0.984 |
ARHGEF6 | PAK1 | ENSBTAP00000023731 | ENSBTAP00000013448 | Rac/Cdc42 guanine nucleotide exchange factor 6. | Serine/threonine-protein kinase PAK 1; Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby media [...] | 0.961 |
ARHGEF6 | PAK2 | ENSBTAP00000023731 | ENSBTAP00000063137 | Rac/Cdc42 guanine nucleotide exchange factor 6. | Non-specific serine/threonine protein kinase. | 0.963 |
ARHGEF6 | PAK3 | ENSBTAP00000023731 | ENSBTAP00000060136 | Rac/Cdc42 guanine nucleotide exchange factor 6. | P21 (RAC1) activated kinase 3. | 0.987 |
ARHGEF6 | PAK6 | ENSBTAP00000023731 | ENSBTAP00000025396 | Rac/Cdc42 guanine nucleotide exchange factor 6. | Non-specific serine/threonine protein kinase. | 0.935 |
ARHGEF6 | RAC2 | ENSBTAP00000023731 | ENSBTAP00000014666 | Rac/Cdc42 guanine nucleotide exchange factor 6. | Ras-related C3 botulinum toxin substrate 2; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase (By similarity). | 0.942 |
ARHGEF6 | RAC3 | ENSBTAP00000023731 | ENSBTAP00000067666 | Rac/Cdc42 guanine nucleotide exchange factor 6. | Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...] | 0.935 |
ARHGEF7 | ARHGEF12 | ENSBTAP00000027619 | ENSBTAP00000073305 | Rho guanine nucleotide exchange factor 7. | Rho guanine nucleotide exchange factor 12. | 0.936 |
ARHGEF7 | ARHGEF6 | ENSBTAP00000027619 | ENSBTAP00000023731 | Rho guanine nucleotide exchange factor 7. | Rac/Cdc42 guanine nucleotide exchange factor 6. | 0.942 |
ARHGEF7 | CDC42 | ENSBTAP00000027619 | ENSBTAP00000059852 | Rho guanine nucleotide exchange factor 7. | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | 0.977 |
ARHGEF7 | GIT1 | ENSBTAP00000027619 | ENSBTAP00000069881 | Rho guanine nucleotide exchange factor 7. | GIT ArfGAP 1. | 0.981 |
ARHGEF7 | PAK1 | ENSBTAP00000027619 | ENSBTAP00000013448 | Rho guanine nucleotide exchange factor 7. | Serine/threonine-protein kinase PAK 1; Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby media [...] | 0.965 |
ARHGEF7 | PAK2 | ENSBTAP00000027619 | ENSBTAP00000063137 | Rho guanine nucleotide exchange factor 7. | Non-specific serine/threonine protein kinase. | 0.971 |